The Unexpected Role of Neutrophils for Resolving Liver Inflammation by Transmitting MicroRNA-223 to Macrophages

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Comment

Adrien Guillot et al. Hepatology. 2020 Feb.

. 2020 Feb;71(2):749-751.

doi: 10.1002/hep.30925. Epub 2019 Dec 31.

¹ Department of Hepatology & Gastroenterology, Charité Universitätsmedizin Berlin, Berlin, Germany.

No abstract available

Comment on

Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223.
Calvente CJ, Tameda M, Johnson CD, Del Pilar H, Lin YC, Adronikou N, De Mollerat Du Jeu X, Llorente C, Boyer J, Feldstein AE. Calvente CJ, et al. J Clin Invest. 2019 Jul 11;129(10):4091-4109. doi: 10.1172/JCI122258. J Clin Invest. 2019. PMID: 31295147 Free PMC article.

1. Huebener P, Pradere JP, Hernandez C, Gwak GY, Caviglia JM, Mu X, et al. The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis. J Clin Invest 2015;125:539-550.
1. Moles A, Murphy L, Wilson CL, Chakraborty JB, Fox C, Park EJ, et al. A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse. J Hepatol 2014;60:782-791.
1. Jimenez Calvente C, Tameda M, Johnson CD, Del Pilar H, Chin Lin Y, Andronikou N, et al. Neutrophils contribute to spontaneous resolution of liver inflammation and fibrosis via microRNA-223. J Clin Invest 2019;130:122258.
1. Yang W, Tao Y, Wu Y, Zhao X, Ye W, Zhao D, et al. Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair. Nat Commun 2019;10:1076.
1. Krenkel O, Hundertmark J, Abdallah AT, Kohlhepp M, Puengel T, Roth T, et al. Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis. Gut 2019 May 10. pii: gutjnl-2019-318382. https://doi.org/10.1136/gutjnl-2019-318382. [Epub ahead of print]