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Review
. 2019 Oct 14;58(42):15154-15158.
doi: 10.1002/anie.201910061. Epub 2019 Sep 11.

Elaborating Complex Heteroaryl-Containing Cycles via Enantioselective Palladium-Catalyzed Cycloadditions

Barry M Trost  1 , Zhiwei Jiao  1 , Chao-I Joey Hung  1
Affiliations
Review

Elaborating Complex Heteroaryl-Containing Cycles via Enantioselective Palladium-Catalyzed Cycloadditions

Barry M Trost et al. Angew Chem Int Ed Engl. .

Abstract

A general method for asymmetric synthesis of heteroaryl-containing cycles via palladium-catalyzed cyclization is reported. Most classes of nitrogen-containing aromatics, including pyridines, quinolines, pyrimidines, various azoles and the derivatives of nucleobases are compatible substrates, offering various heteroaryl-substituted cyclopentane, pyrrolidine, furanidine and bicyclo[4.3.1]decadiene derivatives with good to excellent enantioselectivity and diastereoselectivity.

Keywords: asymmetric catalysis; cycloadditions; heterocycles; palladium; trimethylenemethane.

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References

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