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Comment
. 2019 Sep 3;30(3):405-406.
doi: 10.1016/j.cmet.2019.08.017.

Microglia Metabolic Breakdown Drives Alzheimer's Pathology

F Chris Bennett  1 , Shane A Liddelow  2
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Microglia Metabolic Breakdown Drives Alzheimer's Pathology

F Chris Bennett et al. Cell Metab. .
Free article

Abstract

Altered metabolic function is common in stressed immune cells, but alteration in brain microglia during neurodegeneration is not understood. In this issue, Baik et al. (2019) provide insight into microglial metabolism. They demonstrate a switch from oxidative phosphorylation to glycolysis following interaction with amyloid beta acutely, and breakdown in both pathways chronically.

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