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Review
. 2019 Sep 3;20(17):4318.
doi: 10.3390/ijms20174318.

The Role of the Molecular Clock in Promoting Skeletal Muscle Growth and Protecting against Sarcopenia

Jacopo A Vitale  1 , Matteo Bonato  2 , Antonio La Torre  1   3 , Giuseppe Banfi  1   4
Affiliations
Review

The Role of the Molecular Clock in Promoting Skeletal Muscle Growth and Protecting against Sarcopenia

Jacopo A Vitale et al. Int J Mol Sci. .

Abstract

The circadian clock has a critical role in many physiological functions of skeletal muscle and is essential to fully understand the precise underlying mechanisms involved in these complex interactions. The importance of circadian expression for structure, function and metabolism of skeletal muscle is clear when observing the muscle phenotype in models of molecular clock disruption. Presently, the maintenance of circadian rhythms is emerging as an important new factor in human health, with disruptions linked to ageing, as well as to the development of many chronic diseases, including sarcopenia. Therefore, the aim of this review is to present the latest findings demonstrating how circadian rhythms in skeletal muscle are important for maintenance of the cellular physiology, metabolism and function of skeletal muscle. Moreover, we will present the current knowledge about the tissue-specific functions of the molecular clock in skeletal muscle.

Keywords: Sarcopenia; ageing; function; muscle; orthopaedics; strength.

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Conflict of interest statement

The authors have no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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