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Meta-Analysis
. 2019 Sep 20;39(9):BSR20181853.
doi: 10.1042/BSR20181853. Print 2019 Sep 30.

Can a subgroup at high risk for LRR be identified from T1-2 breast cancer with negative lymph nodes after mastectomy? A meta-analysis

Gongling Peng  1 , Zhuohui Zhou  1 , Ming Jiang  1 , Fan Yang  2
Affiliations
Meta-Analysis

Can a subgroup at high risk for LRR be identified from T1-2 breast cancer with negative lymph nodes after mastectomy? A meta-analysis

Gongling Peng et al. Biosci Rep. .

Abstract

Purpose: To identify a subgroup at high risk for loco-regional recurrence (LRR) from T1-2 breast cancer with negative lymph nodes (N0) after mastectomy by using a meta-analysis.Methods and materials: Published studies on the relationship between clinical features and LRR of breast cancer were identified from public databases, including PubMed, EMBASE, and the Cochrane Library. High-risk features for LRR in this patient population were defined based on the pooled results of meta-analysis.Results: For the meta-analysis, a total of 11244 breast cancers with pT1-2N0 after mastectomy from 20 publications were included for analysis. The pooled results indicated that age (hazard ratio (HR) 1.77, P=0.001), lymphovascular invasion (LVI) (HR 2.23, P<0.001), histologic grade (HR 1.66, P<0.001), HER2 status (HR 1.65, P=0.027), menopausal status (HR 1.36, P=0.015), and surgical margins (HR 2.56, P=0.014) were associated with a significantly increased risk of developing LRR in this patient population group, but not for tumor size (HR 1.32, P=0.23), systematic therapy (HR 1.67, P=0.20), and hormonal receptor status (HR 1.04, P=0.73).Conclusion: In the current study, patients with young age, positive LVI, high histologic grade, HER-2 positive, premenopausal, and positive surgical margins have an increased risk of developing LRR. Further prospective trials are needed to clearly define the role of adjuvant postmastectomy radiotherapy in T1-2N0 breast cancer at high risk of developing LRR.

Keywords: PMRT; breast cancer; local recurrence; risk factors.

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Conflict of interest statement

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1
Figure 1. PRISMA flow diagram
Figure 2
Figure 2. Meta-analysis of LRR rate in young versus elder patients
Figure 3
Figure 3. Meta-analysis of LRR rate in LVI versus no LVI
Figure 4
Figure 4. Meta-analysis of LRR rate in Grade III versus Grade I/II
Figure 5
Figure 5. Meta-analysis of LRR rate in HER2 positive versus HER2 negative
See this image and copyright information in PMC

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