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Randomized Controlled Trial
. 2020 May;34(5):857-863.
doi: 10.1038/s41433-019-0569-x. Epub 2019 Sep 4.

Posterior capsule opacification and Nd:YAG laser rates with two hydrophobic acrylic single-piece IOLs

Daniel Schartmüller  1 , Sabine Schriefl  1 , Luca Schwarzenbacher  1 , Christina Leydolt  1 , Michael Kundi  2 , Stephan Pieh  1 , Rupert Menapace  3 , Katharina Kriechbaum  1
Affiliations
Randomized Controlled Trial

Posterior capsule opacification and Nd:YAG laser rates with two hydrophobic acrylic single-piece IOLs

Daniel Schartmüller et al. Eye (Lond). 2020 May.

Abstract

Objectives: To evaluate the development of posterior capsule opacification (PCO) and Nd:YAG capsulotomy rates following implantation of two hydrophobic acrylic IOLs.

Methods: In a randomized, controlled trial, 80 patients with bilateral senile cataract were implanted with the hydrophobic acrylic single-piece intraocular Lenses (IOLs) EyeCee One in one eye and iMics1 in the other. Outcomes of 39 patients (78 eyes) were evaluated after 3 years. Automated Quantification of After-Cataract (AQUA; for PCO occurrence), visual acuity, anterior fibrosis, capsule-optic edge interaction and distance between anterior and posterior capsule IOL surface were analysed.

Results: After a mean follow-up of 38 ± 1.95 months, Nd:YAG capsulotomy occurred at a rate of 15.4% and 46.2% in the EyeCee One and iMics1 groups, respectively (p < 0.01). Respective mean PCO scores measured by AQUA were 1.57 ± 1.63 and 2.45 ± 1.44 (p = 0.019). A distinct gap between the anterior capsule and the IOL optic was present in 89% of eyes implanted with EyeCee One and 13% of iMics1 eyes. A gap between the posterior capsule and the posterior surface of the lens was observed in 76% of EyeCee One eyes and 35% of iMics1 eyes.

Conclusions: Study findings suggest that PCO and Nd:YAG capsulotomy rates are significantly lower in eyes implanted with the EyeCee One IOL compared to the iMics1 IOL. Optic sharpness and lens material seem to be the decisive factors, while the stepped edge beneath the haptic junction appeared to be ineffective.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
PCO scores among both IOL groups, as measured by AQUA p = 0.019 Wilcoxon. Centre value = Median
Fig. 2
Fig. 2
Examples of observed PCO in the same patient with different IOLs and different AQUA Score. Epithelial lens cell ingrowth over the optic-haptic junction as the main pathway for PCO development was observed in both IOLs
Fig. 3
Fig. 3
Axial and profile view of both IOLs taken with the operating microscope: Left IOL A; right IOL B
See this image and copyright information in PMC

References

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