Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Aug 27:6:12.
doi: 10.1186/s40673-019-0106-5. eCollection 2019.

Nonmotor symptoms in spinocerebellar ataxias (SCAs)

Adriana Moro  1   2 , Mariana Moscovich  3 , Marina Farah  4 , Carlos Henrique F Camargo  5 , Hélio A G Teive  1   5 , Renato P Munhoz  6
Affiliations
Review

Nonmotor symptoms in spinocerebellar ataxias (SCAs)

Adriana Moro et al. Cerebellum Ataxias. .

Abstract

Nonmotor symptoms (NMS) have been increasingly recognized in a number of neurodegenerative diseases with a burden of disability that parallels or even surpasses that induced by motor symptoms. As NMS have often been poorly recognized and inadequately treated, much of the most recent developments in the investigation of these disorders has focused on the recognition and quantification of NMS, which will form the basis of improved clinical care for these complex cases. NMS have been only sparsely investigated in a limited number of spinocerebellar ataxias (SCAs), particularly SCA3, and have not been systematically reviewed for other forms of SCAs. The aim of the present study was to review the available literature on the presence of NMS among different types of SCAs.

Keywords: Nonmotor symptoms; SCA; Spinocerebellar ataxia.

PubMed Disclaimer

Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

References

    1. Klockgether T, Lüdtke R, Kramer B, Abele M, Bürk K, Schöls L, et al. The natural history of degenerative ataxia: a retrospective study in 466 patients. Brain. 1998;121:589–500. doi: 10.1093/brain/121.4.589. - DOI - PubMed
    1. van de Warrenburg BP, Sinke RJ, Verschuuren-Bemelmans CC, Scheffer H, Brunt ER, Ippel PF, et al. Spinocerebellar ataxias in the Netherlands: prevalence and age at onset variance analysis. Neurology. 2002;58:702–708. doi: 10.1212/WNL.58.5.702. - DOI - PubMed
    1. Erichsen AK, Koht J, Stray-Pedersen A, Abdelnoor M, Tallaksen CM. Prevalence of hereditary ataxia and spastic paraplegia in Southeast Norway: a population-based study. Brain. 2009;132:1577–1588. doi: 10.1093/brain/awp056. - DOI - PubMed
    1. Teive HAG. Spinocerebellar ataxias. ArqNeuropsiquiatr. 2009;67:1133–1142. - PubMed
    1. Schöls L, Bauer P, Schmidt T, Schulte T, Riess O. Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis. Lancet Neurol. 2004;3:291–204. doi: 10.1016/S1474-4422(04)00737-9. - DOI - PubMed