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Review
. 2019 Jul 29:2019:1394191.
doi: 10.1155/2019/1394191. eCollection 2019.

Human Lung Microbiome on the Way to Cancer

Olga V Kovaleva  1 , Daniil Romashin  2 , Irina B Zborovskaya  1 , Mikhail M Davydov  3 , Murat S Shogenov  1 , Alexei Gratchev  1   4
Affiliations
Review

Human Lung Microbiome on the Way to Cancer

Olga V Kovaleva et al. J Immunol Res. .

Abstract

Recent research on cancer-associated microbial communities led to the accumulation of data on the interplay between bacteria, immune and tumor cells, the pathways of bacterial induction of carcinogenesis, and its meaningfulness for medicine. Microbial communities that have any kind of impact on tumor progression and microorganisms associated with tumors have been defined as oncobiome. Over the last decades, a number of studies were dedicated to Helicobacter pylori and its role in the progression of stomach tumors, so this correlation can be regarded as proven. Involvement of bacteria in the induction of lung cancer has been largely ignored for a long time, though some correlations between this type of cancer and lung microbiome were established. Despite the fact that in the present the microbial impact on lung cancer progression has many confirmations, the underlying mechanisms are poorly understood. Microorganisms can contribute to tumor initiation and progression through production of bacteriotoxins and other proinflammatory factors. The purpose of this review is to organize the available data on lung cancer microbiome and its role in malignant tumor progression.

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Conflict of interest statement

The authors declare no conflict of interests.

Figures

Figure 1
Figure 1
Interaction of microorganisms with epithelial cells and immune system cells, leading to carcinogenesis.
See this image and copyright information in PMC

References

    1. Yu G., Gail M. H., Consonni D., et al. Characterizing human lung tissue microbiota and its relationship to epidemiological and clinical features. Genome Biology. 2016;17(1):p. 163. doi: 10.1186/s13059-016-1021-1. - DOI - PMC - PubMed
    1. Zhao L. Genomics: the tale of our other genome. Nature. 2010;465(7300):879–880. doi: 10.1038/465879a. - DOI - PubMed
    1. Charlson E. S., Bittinger K., Haas A. R., et al. Topographical continuity of bacterial populations in the healthy human respiratory tract. American Journal of Respiratory and Critical Care Medicine. 2011;184(8):957–963. doi: 10.1164/rccm.201104-0655OC. - DOI - PMC - PubMed
    1. Segal L. N., Blaser M. J. A brave new world: the lung microbiota in an era of change. Annals of the American Thoracic Society. 2014;11(Supplement 1):S21–S27. doi: 10.1513/AnnalsATS.201306-189MG. - DOI - PMC - PubMed
    1. Dickson R. P., Erb-Downward J. R., Huffnagle G. B. Towards an ecology of the lung: new conceptual models of pulmonary microbiology and pneumonia pathogenesis. The Lancet Respiratory Medicine. 2014;2(3):238–246. doi: 10.1016/S2213-2600(14)70028-1. - DOI - PMC - PubMed

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