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. 1988 Dec;79(12):1264-8.
doi: 10.1111/j.1349-7006.1988.tb01554.x.

Production of parathyroid hormone-related protein in adult T-cell leukemia cells

S Honda  1 , K Yamaguchi, Y Miyake, N Hayashi, N Adachi, K Kinoshita, O Ikehara, S Kimura, T Kinoshita, K Shimotohno, et al.
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Production of parathyroid hormone-related protein in adult T-cell leukemia cells

S Honda et al. Jpn J Cancer Res. 1988 Dec.

Abstract

Human parathyroid hormone-related protein (PTHrP) mRNA was detected in peripheral leukemic cells obtained from adult T-cell leukemia (ATL) patients as well as in cultured human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines. In contrast, PTHrP mRNA was not detected in other types of leukemic cells. Using radioimmunoassay, immunoreactive PTHrP was also detected in the spent media of HTLV-I-infected T-cell lines. These results suggest that PTHrP plays an important role in developing the hypercalcemia frequently observed in ATL patients.

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