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Review
. 2019 Sep:24 Suppl 1:e12639.
doi: 10.1111/hel.12639.

Review: Helicobacter pylori in pediatrics

Zrinjka Mišak  1   2 , Iva Hojsak  1   2   3 , Matjaž Homan  4
Affiliations
Review

Review: Helicobacter pylori in pediatrics

Zrinjka Mišak et al. Helicobacter. 2019 Sep.

Abstract

Despite a decrease in the prevalence of Helicobacter pylori infection, it still poses a significant health burden worldwide. This review summarizes important pediatric studies on H pylori published from April 2018 to March 2019. Epidemiologic studies have reported different prevalences in different parts of the world and have mainly confirmed traditional risk factors. Several studies on pathophysiology attempted to identify risk markers in childhood for gastric cancer development later in life. One of the most interesting studies evaluated the relationship between eosinophilic esophagitis and H pylori infection; however, an inverse relationship was not confirmed. The high resistance of H pylori and, consequently, low eradication rates, is still a major concern and susceptibility testing before treatment has again been highlighted. Potassium-competitive acid blockers are promising new acid-suppressant drugs but their role in H pylori eradication schemes is still to be determined.

Keywords: diagnosis; epidemiology; microbiota; resistance; treatment; virulence factors.

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References

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