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Observational Study
. 2020 Jun;59(4):1717-1727.
doi: 10.1007/s00394-019-02026-0. Epub 2019 Sep 5.

Association of artificially sweetened and sugar-sweetened soft drinks with β-cell function, insulin sensitivity, and type 2 diabetes: the Maastricht Study

Louise J C J den Biggelaar  1   2 , Simone J S Sep  3   4 , Andrea Mari  5 , Ele Ferrannini  6 , Martien C J M van Dongen  7   4 , Nicole E G Wijckmans  7   4 , Miranda T Schram  8   9 , Carla J van der Kallen  8 , Nicolaas Schaper  8   3   4 , Ronald M A Henry  8   9 , Marleen M van Greevenbroek  8   4 , Coen D A Stehouwer  8 , Simone J P M Eussen  7   8
Affiliations
Observational Study

Association of artificially sweetened and sugar-sweetened soft drinks with β-cell function, insulin sensitivity, and type 2 diabetes: the Maastricht Study

Louise J C J den Biggelaar et al. Eur J Nutr. 2020 Jun.

Abstract

Purpose: Artificially sweetened and sugar-sweetened beverage consumptions have both been reported to be associated with type 2 diabetes mellitus (T2D) risk. The aim of the current study was to investigate the potential underlying associations with dynamic pancreatic β-cell function (BCF) and insulin sensitivity.

Methods: We evaluated cross-sectional associations in 2240 individuals (mean ± SD age 59.6 ± 8.18, 49.4% male, 21.9% T2D) participating in a diabetes-enriched population-based cohort. Artificially sweetened and sugar-sweetened soft drinks and juice consumption were assessed by a food-frequency questionnaire. Glucose metabolism status, insulin sensitivity, and BCF were measured by a seven-point oral glucose tolerance test. Regression analyses were performed to assess associations of artificially and sugar-sweetened beverage consumption with measures of glucose homeostasis. Associations were adjusted for potential confounders, and additionally with and without total energy intake and BMI, as these variables could be mediators.

Results: Moderate consumption of artificially sweetened soft drink was associated with lower β-cell glucose sensitivity [standardized beta (95% CI), - 0.06 (- 0.11, - 0.02)], total insulin secretion [β - 0.06 (- 0.10, - 0.02)], and with lower β-cell rate sensitivity [odds ratio (95% CI), 1.29 (1.03, 1.62)] compared to abstainers. Daily artificially sweetened soft drink consumption was associated with lower β-cell glucose sensitivity [β - 0.05 (- 0.09, 0.00)], and total insulin secretion [β - 0.05 - 0.09, - 0.01)] compared to abstainers.

Conclusions: Moderate and daily consumption of artificially sweetened soft drinks was associated with lower BCF, but not with insulin sensitivity. No evidence was found for associations of sugar-sweetened soft drink and juice consumption with BCF or insulin sensitivity in this middle-aged population. Prospective studies are warranted to further investigate the associations of artificially and sugar-sweetened beverage consumption with non-fasting insulin sensitivity and multiple BCF aspects.

Keywords: Artificially sweetened beverages; Beta-cell function; Insulin sensitivity; Juice; Soft drink; Sugar-sweetened beverages; T2D.

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Conflict of interest statement

The authors declare that they have no competing interests.

References

    1. World Health Organization . Global report on diabetes. Geneva: World Health Organization; 2016.
    1. Malik VS, Popkin BM, Bray GA, Despres JP, Willett WC, Hu FB. Sugar-sweetened beverages and risk of metabolic syndrome and type 2 diabetes: a meta-analysis. Diabetes Care. 2010;33(11):2477–2483. - PMC - PubMed
    1. Schwingshackl L, Hoffmann G, Lampousi A-M, Knüppel S, Iqbal K, Schwedhelm C, Bechthold A, Schlesinger S, Boeing H. Food groups and risk of type 2 diabetes mellitus: a systematic review and meta-analysis of prospective studies. Eur J Epidemiol. 2017;32(5):363–375. - PMC - PubMed
    1. Ma J, McKeown NM, Hwang SJ, Hoffmann U, Jacques PF, Fox CS. Sugar-sweetened beverage consumption is associated with change of visceral adipose tissue over 6 years of follow-up. Circulation. 2016;133(4):370–377. - PMC - PubMed
    1. Lana A, Rodríguez-Artalejo F, Lopez-Garcia E. Consumption of sugar-sweetened beverages is positively related to insulin resistance and higher plasma leptin concentrations in men and nonoverweight women. J Nutr. 2014;144(7):1099–1105. - PubMed

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