doi: 10.1007/BF02143509.
Cyclization of nucleotide analogues as an obstacle to polymerization
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- PMID: 3148737
- DOI: 10.1007/BF02143509
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Cyclization of nucleotide analogues as an obstacle to polymerization
J Mol Evol.
1988.
Abstract
Cyclization of activated nucleotide analogues by intramolecular phosphodiester-bond formation is likely to compete very effectively with template-directed condensation except in the cases of ribo- and arabinonucleotides. This could have excluded derivatives of most sugars from growing polyribonucleotide chains and thus reduced chain-termination in prebiotic polynucleotide synthesis.
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