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Comment
. 2019 Sep 4;103(5):747-749.
doi: 10.1016/j.neuron.2019.08.019.

Bringing Order out of Chaos: Establishing an Epistatic Relationship between CD33 and TREM2

Timothy Y Huang  1 , Huaxi Xu  2
Affiliations
Comment

Bringing Order out of Chaos: Establishing an Epistatic Relationship between CD33 and TREM2

Timothy Y Huang et al. Neuron. .

Abstract

TREM2 and CD33 are microglial receptors associated with Alzheimer's disease (AD) risk. In this issue of Neuron, Griciuc et al. (2019) demonstrate opposing effects of CD33 and TREM2 on AD phenotypes, where CD33 deletion promotes neuroprotection in a manner dependent on TREM2.

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Figures

Figure 1.
Figure 1.. Exploring the relationship between two microglial immune receptors in AD pathogenesis.
(A) Schematic of TREM2 and CD33 microglial receptors in mouse. Mouse CD33 comprises an “ITIM-like” domain, and lacks a membrane-proximal ITIM present in human microglia. (B) Summary, phenotypes observed in 5xFAD mice with TREM2, CD33 and TREM2/CD33 deletion in combination.
See this image and copyright information in PMC

Comment on

References

    1. Chan G, White CC, Winn PA, Cimpean M, Replogle JM, Glick LR, Cuerdon NE, Ryan KJ, Johnson KA, Schneider JA, et al. (2015). CD33 modulates TREM2: convergence of Alzheimer loci. Nat Neurosci 18, 1556–1558. - PMC - PubMed
    1. Gratuze M, Leyns CEG, and Holtzman DM (2018). New insights into the role of TREM2 in Alzheimer’s disease. Mol Neurodegener 13, 66. - PMC - PubMed
    1. Griciuc A, Patel S, Federico AN, Choi SH, Innes BJ, Oram MK, Cereghetti G, McGinty D, Anselmo A, Sadreyev RL, et al. (2019). TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer’s Disease. Neuron. - PMC - PubMed
    1. Griciuc A, Serrano-Pozo A, Parrado AR, Lesinski AN, Asselin CN, Mullin K, Hooli B, Choi SH, Hyman BT, and Tanzi RE (2013). Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 75, 631–643. - PMC - PubMed
    1. Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, et al. (2013). TREM2 variants in Alzheimer’s disease. N Engl J Med 368, 117–127. - PMC - PubMed