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Review
. 2019 Sep 4;11(9):2085.
doi: 10.3390/nu11092085.

Extra Virgin Olive Oil: Lesson from Nutrigenomics

Stefania De Santis  1   2   3 , Marica Cariello  1 , Elena Piccinin  1 , Carlo Sabbà  1 , Antonio Moschetta  4   5
Affiliations
Review

Extra Virgin Olive Oil: Lesson from Nutrigenomics

Stefania De Santis et al. Nutrients. .

Abstract

Extra virgin olive oil (EVOO) consumption has a beneficial effect on human health, especially for prevention of cardiovascular disease and metabolic disorders. Here we underscore the peculiar importance of specific cultivars used for EVOO production since biodiversity among cultivars in terms of fatty acids and polyphenols content could differently impact on the metabolic homeostasis. In this respect, the nutrigenomic approach could be very useful to fully dissect the pathways modulated by different EVOO cultivars in terms of mRNA and microRNA transcriptome. The identification of genes and miRNAs modulated by specific EVOO cultivars could also help to discover novel nutritional biomarkers for prevention and/or prognosis of human disease. Thus, the nutrigenomic approach depicts a novel scenario to investigate if a specific EVOO cultivar could have a positive effect on human health by preventing the onset of cardiovascular disease and/or chronic inflammatory disorders also leading to cancer.

Keywords: extra virgin olive oil; fatty acids; human health; nutrigenomics; polyphenol content.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Transcriptomic changes induced by high polyphenols VOO and EVOO intake in healthy and unhealthy population. Red arrows: up-modulated genes/miRNAs, green arrows: down-modulated genes/miRNAs. Dashed line indicates an overlapping in the modulation of some genes and miRNAs between inflammation, proliferation and cancer pathways.
See this image and copyright information in PMC

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