Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Sep 10;74(10):1352-1365.
doi: 10.1016/j.jacc.2019.07.043.

Epigenetic Modification in Coronary Atherosclerosis: JACC Review Topic of the Week

Barbara Rizzacasa  1 , Francesca Amati  2 , Francesco Romeo  3 , Giuseppe Novelli  4 , Jawahar L Mehta  5
Affiliations
Free article
Review

Epigenetic Modification in Coronary Atherosclerosis: JACC Review Topic of the Week

Barbara Rizzacasa et al. J Am Coll Cardiol. .
Free article

Abstract

Coronary artery disease (CAD) and its major complication, acute myocardial infarction (AMI), are the leading causes of disability and death worldwide. An individual's risk of developing CAD and MI is modulated by an interplay between genetic and lifestyle factors. It is now clear that epigenetics may play a central role in the development of CAD because epigenetic patterns are affected by the environment and can modulate gene expression. Here, the authors discuss the major epigenetic changes that contribute to CAD and the latest discoveries on the influence of the environment on epigenetic profiles in the development of CAD.

Keywords: coronary artery disease; long noncoding RNA; methylation; microRNA; myocardial infarction.

PubMed Disclaimer

Publication types

LinkOut - more resources