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Review
. 2019 Sep 5;146(17):dev148296.
doi: 10.1242/dev.148296.

RUNX transcription factors: orchestrators of development

Renaud Mevel  1 , Julia E Draper  1 , Michael Lie-A-Ling  1 , Valerie Kouskoff  2 , Georges Lacaud  3
Affiliations
Review

RUNX transcription factors: orchestrators of development

Renaud Mevel et al. Development. .

Abstract

RUNX transcription factors orchestrate many different aspects of biology, including basic cellular and developmental processes, stem cell biology and tumorigenesis. In this Primer, we introduce the molecular hallmarks of the three mammalian RUNX genes, RUNX1, RUNX2 and RUNX3, and discuss the regulation of their activities and their mechanisms of action. We then review their crucial roles in the specification and maintenance of a wide array of tissues during embryonic development and adult homeostasis.

Keywords: Bone; Development; Embryonic; Hematopoiesis; RUNX; T cell.

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Conflict of interest statement

Competing interestsThe authors declare no competing or financial interests.

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