Conflict of interest: B. Hartley reports grant support and medical writing support funded by GlaxoSmithKline, during the conduct of the study; B. Hartley is a contingent worker on assignment at GlaxoSmithKline, and holds shares in GlaxoSmithKline, outside the submitted work. Conflict of interest: G.J. Criner reports grant support and medical writing support funded by GlaxoSmithKline, during the conduct of the study; personal fees from Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi, CSA Medical, Eolo, GlaxoSmithKline, HGE Technologies, Novartis, Nuvaira, Olympus, Pulmonx, Verona and NGM Bio, outside the submitted work. Conflict of interest: M.T. Dransfield reports grant support and medical writing support funded by GlaxoSmithKline, during the conduct of the study; grants from Department of Defense and NIH, has received personal fees for consultancy from and undertaken clinical trials for Boehringer Ingelheim, AstraZeneca, PneumRx/BTG, Boston Scientific and GlaxoSmithKline, undertaken clinical trials for Novartis, Yungjin and Pulmonx, personal fees for consultancy from Genentech and Quark Pharmaceuticals, outside the submitted work. Conflict of interest: D.M.G. Halpin reports grant support and medical writing support funded by GlaxoSmithKline, during the conduct of the study; personal fees from AstraZeneca, Chiesi, GlaxoSmithKline and Pfizer, personal fees and non-financial support from Boehringer Ingelheim and Novartis, outside the submitted work. Conflict of interest: M.K. Han reports grant support and medical writing support funded by GlaxoSmithKline, during the conduct of the study; personal fees from AstraZeneca and Boehringer Ingelheim, grant support from Novartis and Sunovion, outside the submitted work. Conflict of interest: C.E. Jones reports grant support and medical writing support funded by GlaxoSmithKline, during the conduct of the study; C.E. Jones is an employee of and holds shares/options in GlaxoSmithKline, outside the submitted work. Conflict of interest: S. Kilbride reports grant support and medical writing support funded by GlaxoSmithKline, during the conduct of the study; S. Kilbride is an employee of and holds shares/options in GlaxoSmithKline, outside the submitted work. Conflict of interest: P. Lange reports grant support and medical writing support funded by GlaxoSmithKline, during the conduct of the study; personal fees from GlaxoSmithKline, AstraZeneca, Boehringer Ingelheim and Chiesi, outside the submitted work. Conflict of interest: D.A. Lipson reports grant support and medical writing support funded by GlaxoSmithKline, during the conduct of the study; D.A. Lipson is an employee of and holds shares/options in GlaxoSmithKline, outside the submitted work. Conflict of interest: D.A. Lomas reports grant support and medical writing support funded by GlaxoSmithKline, during the conduct of the study; grants, personal fees for consultancy and honoraria from GlaxoSmithKline, personal fees for consultancy from Grifols, outside the submitted work. Conflict of interest: N. Martin reports grant support and medical writing support funded by GlaxoSmithKline, during the conduct of the study; N. Martin is an employee of and holds shares/options in GlaxoSmithKline, outside the submitted work. Conflict of interest: F.J. Martinez reports grant support and medical writing support funded by GlaxoSmithKline, during the conduct of the study; personal fees and travel support for educational activities from American College of Chest Physicians, Inova Fairfax Health System, MD Magazine, Miller Communications, National Association for Continuing Education, PeerView Communications, Prime Communications, Puerto Rican Respiratory Society, Potomac, University of Alabama Birmingham, Physicians Education Resource, Canadian Respiratory Network and Dartmouth, personal fees for advisory board work, steering committee work and lectures, and travel support from AstraZeneca, personal fees for advisory board work, data monitoring committee work and lectures, and travel support from Boehringer Ingelheim and Genentech, non-financial support for advisory board work from ProterrixBio, personal fees for educational activities from Columbia University, Integritas, Methodist Hospital Brooklyn, New York University, UpToDate, WebMD/MedScape, Western Connecticut Health Network, PlatformIQ, Rockpointe, Rare Disease Healthcare Communications and France Foundation, personal fees for advisory board work and travel support from ConCert, Sunovion, Theravance and Teva, personal fees for advisory board work and non-financial support for travel, lecturing, steering committee work and data monitoring committee work from GlaxoSmithKline, personal fees for advisory board work and lectures, and travel support from Novartis, personal fees for advisory board work and non-financial support for steering committee work from Pearl Pharmaceuticals, personal fees for advisory board work and educational activites, and travel support from Chiesi, non-financial support for steering committee work from Afferent/Merck, Gilead, Nitto, Veracyte, Prometic, Bayer and ProMedior, personal fees for consultancy and steering committee work from Patara/Respivant, non-financial support for data monitoring committee and steering committee work from Biogen, non-financial support for lecturing and advisory board work from Zambon, personal fees for journal editorship from American Thoracic Society, grants from NIH, non-financial support for consultancy from Bridge Biotherapeutics, outside the submitted work. Conflict of interest: D. Singh reports grant support and medical writing support funded by GlaxoSmithKline, during the conduct of the study; personal fees from GlaxoSmithKline, Cipla, Genentech and Peptinnovate, grants and personal fees from AstraZeneca, Boehringer Ingleheim, Chiesi, Glenmark, Menarini, Mundipharma, Novartis, Pfizer, Pulmatrix, Therevance and Verona, outside the submitted work. Conflict of interest: R.A. Wise reports grant support and medical writing support funded by GlaxoSmithKline, personal fees for data monitoring committee and advisory board work from GlaxoSmithKline, during the conduct of the study; grants and personal fees for data monitoring committee and consultancy work from AstraZeneca/Medimmune and GSK, grants and personal fees for data monitoring and steering committee work from Boehringer Ingelheim, personal fees for clinical end-point committee work from Contrafect, personal fees for data monitoring committee work from Pulmonx, Roche, Merck and AbbVie, personal fees for steering committee work from Spiration, personal fees for workshops and consultancy from Sunovion, grants from Pearl Therapeutics and Sanofi-Aventis, personal fees for consultancy from Circassia, Pneuma, Verona, Denali, Aradigm, Mylan/Theravance and Propelloer Health, personal fees for safety review committee work from Bonti, outside the submitted work. Conflict of interest: S. Lettis reports grant support and medical writing support funded by GlaxoSmithKline, during the conduct of the study; S. Lettis is an employee of and holds shares/options in GlaxoSmithKline, outside the submitted work.