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. 2020 Mar;28(3):287-299.
doi: 10.1038/s41431-019-0496-0. Epub 2019 Sep 5.

The Dutch Y-chromosomal landscape

Eveline Altena  1 , Risha Smeding  1 , Kristiaan J van der Gaag  1   2 , Maarten H D Larmuseau  3   4   5 , Ronny Decorte  3   6 , Oscar Lao  7   8   9 , Manfred Kayser  7 , Thirsa Kraaijenbrink  1 , Peter de Knijff  10
Affiliations

The Dutch Y-chromosomal landscape

Eveline Altena et al. Eur J Hum Genet. 2020 Mar.

Erratum in

  • Correction to: The Dutch Y-chromosomal landscape.
    Altena E, Smeding R, van der Gaag KJ, Larmuseau MHD, Decorte R, Lao O, Kayser M, Kraaijenbrink T, de Knijff P. Altena E, et al. Eur J Hum Genet. 2020 Mar;28(3):399. doi: 10.1038/s41431-019-0528-9. Eur J Hum Genet. 2020. PMID: 31645767 Free PMC article.

Abstract

Previous studies indicated existing, albeit limited, genetic-geographic population substructure in the Dutch population based on genome-wide data and a lack of this for mitochondrial SNP based data. Despite the aforementioned studies, Y-chromosomal SNP data from the Netherlands remain scarce and do not cover the territory of the Netherlands well enough to allow a reliable investigation of genetic-geographic population substructure. Here we provide the first substantial dataset of detailed spatial Y-chromosomal haplogroup information in 2085 males collected across the Netherlands and supplemented with previously published data from northern Belgium. We found Y-chromosomal evidence for genetic-geographic population substructure, and several Y-haplogroups demonstrating significant clinal frequency distributions in different directions. By means of prediction surface maps we could visualize (complex) distribution patterns of individual Y-haplogroups in detail. These results highlight the value of a micro-geographic approach and are of great use for forensic and epidemiological investigations and our understanding of the Dutch population history. Moreover, the previously noted absence of genetic-geographic population substructure in the Netherlands based on mitochondrial DNA in contrast to our Y-chromosome results, hints at different population histories for women and men in the Netherlands.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Map of the Netherlands with sample locations and province names
Fig. 2
Fig. 2
Typed SNPs in phylogenetic trees, grouped in the core set and the E-M96, E1b-M2, and R1b-M415 multiplex assays. Monoplexes are marked gray. SNP P143 in the core set multiplex was not typed but recommended instead of M168
Fig. 3
Fig. 3
Graph of YHG proportions in the Dutch dataset
Fig. 4
Fig. 4
a Plot of the first two dimensions from the classical multidimensional scaling analysis. b Plot of the first two dimensions from the correspondence analysis without outliers. Sample locations are colored by province
Fig. 5
Fig. 5
Prediction surface maps of the four most frequent (sub-)YHGs in the Dutch dataset in phylogenetic order
See this image and copyright information in PMC

References

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