Long-term effects of functional appliances in treated versus untreated patients with Class II malocclusion: A systematic review and meta-analysis

Abstract

Objective: To assess the cephalometric skeletal and soft-tissue of functional appliances in treated versus untreated Class II subjects in the long-term (primarily at the end of growth, secondarily at least 3 years after retention).

Search methods: Unrestricted electronic search of 24 databases and additional manual searches up to March 2018.

Selection criteria: Randomised and non-randomised controlled trials reporting on cephalometric skeletal and soft-tissue measurements of Class II patients (aged 16 years or under) treated with functional appliances, worn alone or in combination with multi-bracket therapy, compared to untreated Class II subjects.

Data collection and analysis: Mean differences (MDs) and 95% confidence intervals (95% CIs) were calculated with the random-effects model. Data were analysed at 2 primary time points (above 18 years of age, at the end of growth according to the Cervical Vertebral Maturation method) and a secondary time point (at least 3 years after retention). The risk of bias and quality of evidence were assessed according to the ROBINS tool and GRADE system, respectively.

Results: Eight non-randomised studies published in 12 papers were included. Functional appliances produced a significant improvement of the maxillo-mandibular relationship, at almost all time points (Wits appraisal at the end of growth, MD -3.52 mm, 95% CI -5.11 to -1.93, P < 0.0001). The greatest increase in mandibular length was recorded in patients aged 18 years and above (Co-Gn, MD 3.20 mm, 95% CI 1.32 to 5.08, P = 0.0009), although the improvement of the mandibular projection was negligible or not significant. The quality of evidence was 'very low' for most of the outcomes at both primary time points.

Conclusions: Functional appliances may be effective in correcting skeletal Class II malocclusion in the long-term, however the quality of the evidence was very low and the clinical significance was limited.

Systematic review registration: CRD42018092139.

Fig 1. PRISMA flow diagram.

Fig 2. Meta-analysis; Outcome: SNA angle; Time point: End of growth according to the CVM method.

Fig 3. Meta-analysis; Outcome: Co-Gn distance; Time point: Above 18 years of age.

Fig 4. Meta-analysis; Outcome: Co-Gn distance; Time point: End of growth according to the CVM method.

Fig 5. Meta-analysis; Outcome: ANB angle; Time point: End of growth according to the CVM method.

Fig 6. Meta-analysis; Outcome: Wits appraisal; Time point: End of growth according to the CVM method.

Fig 7. Meta-analysis; Outcome: Co-Gn/Co-A difference; Time point: End of growth according to the CVM method.