Emerging trends in paper spray mass spectrometry: Microsampling, storage, direct analysis, and applications
- PMID: 31491055
- PMCID: PMC7875099
- DOI: 10.1002/mas.21601
Emerging trends in paper spray mass spectrometry: Microsampling, storage, direct analysis, and applications
Abstract
Recent advancements in the sensitivity of chemical instrumentation have led to increased interest in the use of microsamples for translational and biomedical research. Paper substrates are by far the most widely used media for biofluid collection, and mass spectrometry is the preferred method of analysis of the resultant dried blood spot (DBS) samples. Although there have been a variety of review papers published on DBS, there has been no attempt to unify the century old DBS methodology with modern applications utilizing modified paper and paper-based microfluidics for sampling, storage, processing, and analysis. This critical review will discuss how mass spectrometry has expanded the utility of paper substrates from sample collection and storage, to direct complex mixture analysis to on-surface reaction monitoring.
Keywords: ambient ionization; direct analysis; direct reaction monitoring by paper spray; dried blood spot (DBS); mass spectrometry; microfluidic devices; microsampling; paper spray (PS); solid-phase extraction.
© 2019 John Wiley & Sons Ltd.
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References
-
- Adam BW, Alexander JR, Smith SJ, Chace DH, Loeber JG, Elvers LH, and Hannon WH 2000. Recoveries of Phenylalanine from Two Sets of Dried-Blood Spot Reference Materials: Predition from Hematocrit, Spot Volume, and Paper Matrix. Clinical Chemistry. 46:126–128. - PubMed
-
- Alberici RM, Simas RC, Sanvido GB, Romão W, Lalli PM, Benassi M, Cunha IBS, and Eberlin MN 2010. Ambient mass spectrometry: bringing MS into the “real world.” Anal Bioanal Chem. 398:265–294. - PubMed
-
- Alfazil AA, and Anderson RA 2008. Stability of Benzodiazepines and Cocaine in Blood Spots Stored on Filter Paper. Journal of Analytical Toxicology. 32:511–515. - PubMed
-
- Aliaga-Aguilar H 2018. Characterization and Analysis of Paper Spray Ionization of Organic Compounds. Journal of The American Society for Mass Spectrometry. 29:17–25. - PubMed
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