The Face of Chromatin Variants
- PMID: 31491382
- DOI: 10.1016/j.cell.2019.08.024
The Face of Chromatin Variants
Abstract
A developmental program affecting human face shape is shown by Greenberg et al. (2019) to hinge on the ability to distinguish a single methyl group between two histone variant isoforms and the action of the chromatin-remodeling enzyme SRCAP. This challenges researchers to link atomic structure to a morphological defect.
Copyright © 2019 Elsevier Inc. All rights reserved.
Comment on
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Single Amino Acid Change Underlies Distinct Roles of H2A.Z Subtypes in Human Syndrome.Cell. 2019 Sep 5;178(6):1421-1436.e24. doi: 10.1016/j.cell.2019.08.002. Cell. 2019. PMID: 31491386 Free PMC article.
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