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Review
. 2019 Sep 5;20(18):4347.
doi: 10.3390/ijms20184347.

Risk Factors for the Development of Psoriasis

Koji Kamiya  1 , Megumi Kishimoto  2 , Junichi Sugai  3 , Mayumi Komine  4 , Mamitaro Ohtsuki  5
Affiliations
Review

Risk Factors for the Development of Psoriasis

Koji Kamiya et al. Int J Mol Sci. .

Abstract

Psoriasis is an immune-mediated genetic skin disease. The underlying pathomechanisms involve complex interaction between the innate and adaptive immune system. T cells interact with dendritic cells, macrophages, and keratinocytes, which can be mediated by their secreted cytokines. In the past decade, biologics targeting tumor necrosis factor-α, interleukin (IL)-23, and IL-17 have been developed and approved for the treatment of psoriasis. These biologics have dramatically changed the treatment and management of psoriasis. In contrast, various triggering factors can elicit the disease in genetically predisposed individuals. Recent studies suggest that the exacerbation of psoriasis can lead to systemic inflammation and cardiovascular comorbidity. In addition, psoriasis may be associated with other auto-inflammatory and auto-immune diseases. In this review, we summarize the risk factors, which can be divided into two groups (namely, extrinsic and intrinsic risk factors), responsible for the onset and exacerbation of psoriasis in order to facilitate its prevention.

Keywords: exacerbation; extrinsic risk factor; intrinsic risk factor; onset; psoriasis; risk factor.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Risk factors for the onset and exacerbation of psoriasis. As shown in this figure, extrinsic and intrinsic factors are associated with the onset and exacerbation of psoriasis.
See this image and copyright information in PMC

References

    1. Boehncke W.H., Schon M.P. Psoriasis. Lancet. 2015;386:983–994. doi: 10.1016/S0140-6736(14)61909-7. - DOI - PubMed
    1. Nestle F.O., Kaplan D.H., Barker J. Psoriasis. N. Engl. J. Med. 2009;361:496–509. doi: 10.1056/NEJMra0804595. - DOI - PubMed
    1. Parisi R., Symmons D.P., Griffiths C.E., Ashcroft D.M., IMPACT project team Global epidemiology of psoriasis: A systematic review of incidence and prevalence. J. Invest. Dermatol. 2013;133:377–385. doi: 10.1038/jid.2012.339. - DOI - PubMed
    1. Michalek I.M., Loring B., John S.M. A systematic review of worldwide epidemiology of psoriasis. J. Eur. Acad. Dermatol. Venereol. 2017;31:205–212. doi: 10.1111/jdv.13854. - DOI - PubMed
    1. Trembath R.C., Clough R.L., Rosbotham J.L., Jones A.B., Camp R.D., Frodsham A., Browne J., Barber R., Terwilliger J., Lathrop G.M., et al. Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis. Hum. Mol. Genet. 1997;6:813–820. doi: 10.1093/hmg/6.5.813. - DOI - PubMed