Reduction of macrophage-mediated tumor cytotoxicity by pretreatment with GM-CSF
Affiliations
- PMID: 3149190
Item in Clipboard
Reduction of macrophage-mediated tumor cytotoxicity by pretreatment with GM-CSF
Behring Inst Mitt.
1988 Aug.
Abstract
The effect of granulocyte/macrophage colony stimulating factor (GM-CSF) on macrophage activation by interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS) was studied in a murine model system. When peritoneal macrophages were pretreated with GM-CSF for 24 hrs, a strong reduction of IFN-gamma-induced tumor cytotoxicity and LPS-triggered tumor necrosis factor-alpha (TNF-alpha) release was found. In contrast, GM-CSF treatment of macrophages for only 4 to 8 hrs enhanced TNF-alpha production. These data suggest that GM-CSF may affect macrophage activation in a biphasic manner in that a time period of enhanced responsiveness to IFN-gamma is followed by a longlasting period of refractoriness.
Similar articles
-
Macrophage activation by granulocyte/macrophage colony-stimulating factor. Priming for enhanced release of tumor necrosis factor-alpha and prostaglandin E2.J Immunol. 1989 Aug 15;143(4):1198-205. J Immunol. 1989. PMID: 2473121
-
Granulocyte-macrophage colony-stimulating factor and IFN-gamma restore the systemic TNF-alpha response to endotoxin in lipopolysaccharide-desensitized mice.J Immunol. 1997 Mar 15;158(6):2862-71. J Immunol. 1997. PMID: 9058823
-
Temporally different stimulation of TNF-alpha and PGE2 release from GM-CSF-primed macrophages.Lymphokine Res. 1989 Fall;8(3):353-7. Lymphokine Res. 1989. PMID: 2674560
-
The expression and target cell specificity of human granulocyte-macrophage colony-stimulating factor.Year Immunol. 1988;3:144-51. Year Immunol. 1988. PMID: 2831680 Review. No abstract available.
-
A potential role of macrophage activation in the treatment of cancer.Crit Rev Oncol Hematol. 2002 Nov;44(2):143-61. doi: 10.1016/s1040-8428(01)00203-7. Crit Rev Oncol Hematol. 2002. PMID: 12413632 Review.