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Review
. 2019 Sep 5;11(9):1312.
doi: 10.3390/cancers11091312.

Neuromedin U: A Small Peptide in the Big World of Cancer

Patrycja Przygodzka  1 , Kamila Soboska  2   3 , Ewelina Sochacka  2   3 , Joanna Boncela  4
Affiliations
Review

Neuromedin U: A Small Peptide in the Big World of Cancer

Patrycja Przygodzka et al. Cancers (Basel). .

Erratum in

Abstract

Neuromedin U (NMU), a neuropeptide isolated from porcine spinal cord and named because of its activity as a rat uterus smooth muscle contraction inducer, is emerging as a new player in the tumorigenesis and/or metastasis of many types of cancers. Expressed in a variety of tissues, NMU has been shown to possess many important activities in the central nervous system as well as on the periphery. Along with the main structural and functional features of NMU and its currently known receptors, we summarized a growing number of recently published data from different tissues and cells that associate NMU activity with cancer development and progression. We ask if, based on current reports, NMU can be included as a marker of these processes and/or considered as a therapeutic target.

Keywords: GPCR receptors; NMU; Neuromedin U; cancer.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The current paradigm of neuromedin U signalling.
Figure 2
Figure 2
NMU expression and activity is regulated at multiple cellular levels.
See this image and copyright information in PMC

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