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Comment
. 2019 Sep 6;23(1):305.
doi: 10.1186/s13054-019-2586-3.

Neuromuscular blocking agents for acute respiratory distress syndrome: how did we get conflicting results?

Heather Torbic  1 , Sudhir Krishnan  2 , Abhijit Duggal  2
Affiliations
Comment

Neuromuscular blocking agents for acute respiratory distress syndrome: how did we get conflicting results?

Heather Torbic et al. Crit Care. .
No abstract available

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Conflict of interest statement

The authors declare they have no competing interests.

Comment on

  • Neuromuscular blockers in early acute respiratory distress syndrome.
    Papazian L, Forel JM, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, Jaber S, Arnal JM, Perez D, Seghboyan JM, Constantin JM, Courant P, Lefrant JY, Guérin C, Prat G, Morange S, Roch A; ACURASYS Study Investigators. Papazian L, et al. N Engl J Med. 2010 Sep 16;363(12):1107-16. doi: 10.1056/NEJMoa1005372. N Engl J Med. 2010. PMID: 20843245 Clinical Trial.
  • Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.
    National Heart, Lung, and Blood Institute PETAL Clinical Trials Network; Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus DC. National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, et al. N Engl J Med. 2019 May 23;380(21):1997-2008. doi: 10.1056/NEJMoa1901686. Epub 2019 May 19. N Engl J Med. 2019. PMID: 31112383 Free PMC article. Clinical Trial.

References

    1. Alhazzani W, Alshahrani M, Jaeschke R, Forel JM, Papazian L, Sevransky J, et al. Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials. Critical Care. 2013;17(2):R43. doi: 10.1186/cc12557. - DOI - PMC - PubMed
    1. Papazian L, Forel JM, Gacouin A, Penot-Ragon C, Perrin G, Loundou A, et al. Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med. 2010;363(12):1107–1116. doi: 10.1056/NEJMoa1005372. - DOI - PubMed
    1. Bellani G, Laffey JG, Pham T, Fan E, Brochard L, Esteban A, et al. Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries. JAMA. 2016;315(8):788–800. doi: 10.1001/jama.2016.0291. - DOI - PubMed
    1. Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, et al. Early neuromuscular blockade in the acute respiratory distress syndrome. N Engl J Med. 2019;380(21):1997–2008. doi: 10.1056/NEJMoa1901686. - DOI - PMC - PubMed
    1. Slutsky AS, Villar J. Early paralytic agents for ARDS? Yes, no, and sometimes. N Engl J Med. 2019;380(21):2061–2063. doi: 10.1056/NEJMe1905627. - DOI - PubMed

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