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Comment
. 2019 Oct;40(10):714-716.
doi: 10.1016/j.tips.2019.08.007. Epub 2019 Sep 5.

Interleukin-13 Is Unlucky for Allergy Sufferers

Markus M Xie  1 , Alexander L Dent  2
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Interleukin-13 Is Unlucky for Allergy Sufferers

Markus M Xie et al. Trends Pharmacol Sci. 2019 Oct.
Free article

Abstract

Anaphylaxis, a life-threatening allergic reaction, is dependent on high affinity allergen-specific IgE. Gowthaman et al. now show that a new interleukin (IL)-13-expressing T helper cell subset specifically promotes high-affinity IgE responses. The discovery of T follicular helper (Tfh)13 cells defines potential new targets for allergy therapies.

Keywords: Tfh13; allergy; anaphylaxis.

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  • Identification of a T follicular helper cell subset that drives anaphylactic IgE.
    Gowthaman U, Chen JS, Zhang B, Flynn WF, Lu Y, Song W, Joseph J, Gertie JA, Xu L, Collet MA, Grassmann JDS, Simoneau T, Chiang D, Berin MC, Craft JE, Weinstein JS, Williams A, Eisenbarth SC. Gowthaman U, et al. Science. 2019 Aug 30;365(6456):eaaw6433. doi: 10.1126/science.aaw6433. Epub 2019 Aug 1. Science. 2019. PMID: 31371561 Free PMC article.