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Review
. 1988 Sep;4(1):83-90.
doi: 10.3109/08830188809044772.

In vivo modulation of murine collagen induced arthritis

G E Ranges  1 , S Fortin, M T Barger, S Sriram, S M Cooper
Affiliations
Review

In vivo modulation of murine collagen induced arthritis

G E Ranges et al. Int Rev Immunol. 1988 Sep.

Abstract

The effects of in vivo modulation of murine collagen induced arthritis with monoclonal anti-CD4 antibodies, monoclonal anti-Ia antibodies, and gamma interferon are reviewed. We detail the mechanism of action of monoclonal anti-CD4 antibody on humoral and cell mediated immune responses and discuss the implications for designing therapeutic strategies. To further explore the induction of collagen induced arthritis, a syngeneic cell transfer system using collagen primed T lymphocytes is described. This cell transfer system provides an opportunity to study the role of CD4 positive T lymphocytes in arthritis induction during a short, defined time period.

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