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. 2019 Aug 8:12:6267-6273.
doi: 10.2147/OTT.S212752. eCollection 2019.

PIM-1 kinase: a potential biomarker of triple-negative breast cancer

Jieying Chen  1 , Guangyu Tang  1
Affiliations

PIM-1 kinase: a potential biomarker of triple-negative breast cancer

Jieying Chen et al. Onco Targets Ther. .

Abstract

Triple-negative breast cancer is associated with a poor prognosis, and effective biomarkers for targeted diagnosis and treatment are lacking. The tumorigenicity of the provirus integration site for Moloney murine leukemia virus 1 (PIM-1) gene has been studied for many years. However, its significance in breast cancer remains unclear. In this review we briefly summarized the physiological characteristics and regulation of PIM-1 kinase, and subsequently focused on the role of PIM-1 in tumors, especially breast cancer. Oncogene PIM-1 was found to be upregulated in breast cancer, especially in triple-negative breast cancer. Moreover, it is involved in tumorigenesis and the development of drug resistance, and linked to poor prognosis. A highly selective probe targeting PIM-1 for imaging has emerged, suggesting that PIM-1 may be a potential biomarker for the accurate diagnosis and targeted therapy of triple-negative breast cancer.

Keywords: PIM-1; biomarker; triple-negative breast cancer.

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Conflict of interest statement

The authors report no conflict of interest in this work.

Figures

Figure 1
Figure 1
PIM-1 gene and its transcripts and proteins.
See this image and copyright information in PMC

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