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. 2019 Aug 9:11:7567-7575.
doi: 10.2147/CMAR.S209418. eCollection 2019.

The prognostic value of preoperative controlling nutritional status score in non-metastatic renal cell carcinoma treated with surgery: a retrospective single-institution study

Haifeng Song #  1   2   3 , Ben Xu #  1   2   3 , Cheng Luo  1   2   3 , Zhenan Zhang  1   2   3 , Binglei Ma  1   2   3 , Jie Jin  1   2   3 , Qian Zhang  1   2   3
Affiliations

The prognostic value of preoperative controlling nutritional status score in non-metastatic renal cell carcinoma treated with surgery: a retrospective single-institution study

Haifeng Song et al. Cancer Manag Res. .

Abstract

Purpose: This study aimed to investigate the significance of the controlling nutritional status (CONUT) score as a predictor for survival outcomes for non-metastatic renal cell carcinoma (RCC) patients.

Methods: We retrospectively reviewed 325 patients who received surgical treatment for renal cell carcinoma between 2010 and 2012 at Peking University First Hospital. Patients were divided into two groups according to the optimal cut-off value of CONUT score. Kaplan-Meier method and log-rank test were used for survival analysis according to different CONUT groups. Cox proportional hazards regression models were performed to assess the prognostic value of clinicopathological parameters for overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS) respectively.

Results: The optimal cut-off value of CONUT score was 3. High CONUT score significantly correlated to higher tumor grade (P<0.001), later pathological T stage (P<0.001) and tumor necrosis (P<0.001). Patients with higher CONUT score had worse OS (HR 5.34, 95% CI 2.29-12.46, P<0.001), CSS (HR 5.51, 95% CI 2.12-14.33, P<0.001) and DFS (HR 4.23, 95% CI 2.16-8.29, P<0.001). In multivariable analysis, high CONUT score was an independent risk factor for OS, CSS and DFS (OS: HR=3.36, 95% CI 1.73-6.56, P<0.001; CSS: HR=3.34, 95% CI 1.59-6.98, P=0.001; DFS: HR=1.85, ]95% CI 1.07-3.21, P=0.029).

Conclusion: Preoperative CONUT score was an independent prognostic factor for OS, CSS and DFS in non-metastatic RCC patients treated with surgery.

Keywords: CONUT score; biomarker; renal cell carcinoma; surgery; survival.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
ROC curve for CONUT score. Abbreviations: ROC, receiver operating characteristic; CONUT score, controlling nutritional status score.
Figure 2
Figure 2
Kaplan–Meier survival curves for non-metastatic RCC patients treated with surgery. Survival curves set at cut-off value 2 for OS (A), CSS (B) and DFS (C). Abbreviations: RCC, renal cell carcinoma; OS, overall survival; CSS, cancer-specific survival; DFS, disease-free survival; CONUT, controlling nutritional status.
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