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. 2019 Mar 26;38(4):427-436.
doi: 10.2478/jomb-2019-0012. eCollection 2019 Oct.

Body Mass Index and C-reactive Protein Are Potential Predictors of Asthma Development in Egyptian Polycystic Ovary Syndrome Patients

Hebatallah Ahmed Nasser  1 , Nermeen Zakaria Abuel Ezz  2 , Heidi Mohamed Abdel-Mageed  3   4 , Rasha Ali Radwan  5
Affiliations

Body Mass Index and C-reactive Protein Are Potential Predictors of Asthma Development in Egyptian Polycystic Ovary Syndrome Patients

Hebatallah Ahmed Nasser et al. J Med Biochem. .

Abstract
in English, Serbian

Background: Recent studies suggest asthma prevalence in polycystic ovary syndrome (PCOS) patients. This is the first study to explore asthma prevalence among Egyptian PCOS patients. It highlighted common findings in PCOS and asthma. It investigated whether these findings could serve as potential predictors of asthma.

Methods: A hundred PCOS patients, sixty asthmatic patients and thirty apparently healthy females of matched age were included. Body mass index (BMI), C-reactive protein (CRP), IL-6, IgE, 25 (OH) vitamin D, testosterone and lipid profile were measured.

Results: Both PCOS and asthmatics had significantly higher BMI, Total cholesterol (TC), LDL-C, IgE, CRP and IL-6 (P<0.001) and lower 25 (OH) vitamin D levels (P<0.001) compared to controls. Within the PCOS group, 47 patients developed asthma with a significant increase in BMI (P=0.003), CRP and IgE levels (P<0.001) compared to non-asthmatic PCOS. Both asthmatic PCOS and asthmatics expressed elevated BMI, IgE, IL-6 and CRP levels, but with no significant difference between them. Asthmatic PCOS showed significantly higher testosterone and dyslipidemia profile. Multivariate regression revealed that BMI and CRP could predict asthma development within PCOS (OR=1.104, C.I 1.004-1.2 and OR=1, C.I. 1-1.02), respectively. Receiver operating characteristic (ROC) curve showed that BMI and CRP at a cutoff value 28.5 kg/m2 and 117.6 nmol/L respectively could differentiate between asthmatic and non-asthmatic PCOS with sensitivity 63.8 % and specificity 62% for BMI, and sensitivity and specificity of 66% for CRP.

Conclusions: This study shows that BMI and CRP are predictors of asthma development in Egyptian PCOS.

Uvod: Nedavne studije ukazuju na prevalenciju astme kod pacijentkinja sa sindromom policističnih jajnika (PCOS). Ovo je prva studija koja je istraživala prevalenciju astme među egipatskim PCOS pacijentkinjama i dala je uobičajene nalaze u vezi sa PCOS i astmom. Osim toga, studija je bavi i istraživanjem da li ovi nalazi mogu poslužiti kao potencijalni prediktori astme.

Metode: Uključeno je 100 pacijentkinja sa PCOS, šezdeset pacijentkinja sa astmom i trideset očigledno zdravih žena odgovarajuće starosti. Izmereni su indeks telesne mase (BMI), C-reaktivni protein (CRP), IL-6, IgE, 25 (OH) vitamin D, testosteron i lipidni profil.

Rezultati: I pacijentkinje sa PCOS i one sa astmom su imale značajno veći BMI, ukupni holesterol (TC), LDL-C, IgE, CRP i IL-6 (P < 0,001) i niže nivoe vitamina D (P < 0,001) u odnosu na pacijentkinje u kontrolnoj grupi. U okviru PCOS grupe, 47 pacijentkinja je razvilo astmu sa značajnim porastom BMI (P = 0,003), CRP i IgE nivoa (P < 0,001) u poređenju sa ne-astmatičnim PCOS. I astmatične pacijentkinje sa PCOS i one bez PCOS su imale povišene nivoe BMI, IgE, IL-6 i CRP, ali bez značajne razlike između njih. Astmatične PCOS pacijentkinje su pokazale značajno veći testosteronski i dislipidemijski profil. Multivarijantna regresija je pokazala da BMI i CRP mogu predvideti razvoj astme unutar PCOS grupe (OR=1,104, C.I 1,004–1,2 i OR=1, C.I. 1–1,02), respektivno. ROC kriva je pokazala da se BMI i CRP kod graničnih vrednosti 28,5 kg/m2 i 117,6 nmol/L mogu razlikovati između astmatičnih i neastmatičnih PCOS sa osetljivošću 63,8% i specifičnošću 62% za BMI, dok je osetljivost i specifičnost za CRP 66%.

Zaključak: Zaključak: Ova studija pokazuje da su BMI i CRP prediktori razvoja astme kod pacijentkinja sa sindromom policističnih jajnika u Egiptu.

Keywords: BMI; CRP; IgE; asthma; dyslipidemia; interleukin 6; polycystic ovary syndrome.

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Conflict of interest statement

Conflict of interest Conflict of interest statement: The authors stated that they have no conflicts of interest regarding the publication of this article.

Figures

Figure 1
Figure 1
ROC curve illustrating the potential of BMI and CRP to differentiate between asthmatic and non-asthmatic PCOS patients. At area under the curve (AUC=0.67, P=0.003), the optimal cutoff value for BMI is 28.5 kg/m2 with sensitivity 63.8 % and specificity 62%, whereas the optimal cutoff value of CRP level is 117.6 nmol/L with sensitivity and specificity 66% at (AUC= 0.69, P=0.001.)
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