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. 2019 Jul-Sep;14(3):754-758.
doi: 10.4103/ajns.AJNS_127_19.

Pituitary Prolactinoma with Amyloid Deposits: Surgery or Dopamine Agonists? Review of Previous Reports and New Recommendations for Management

Santosh Prabhu  1 , Sujata Prabhu  2
Affiliations

Pituitary Prolactinoma with Amyloid Deposits: Surgery or Dopamine Agonists? Review of Previous Reports and New Recommendations for Management

Santosh Prabhu et al. Asian J Neurosurg. 2019 Jul-Sep.

Abstract

Background: Pituitary adenomas, macro and micro, are a common occurrence in most neurosurgical centers. Prolactinomas are the most common pituitary tumors and are often treated nowadays with dopamine agonists such as cabergoline, with good results.

Aims and objectives: To suggest new therapeutic guidelines for treating Prolactinomas with Amyloid deposits on preoperative detection of Amyloid deposition in Pituitary tumors, based on MRI characteristics.

Materials and methods: We report a case of a pituitary prolactinoma with amyloid deposits in a 45-year-old male who underwent a transsphenoidal excision of the adenoma. Although on magnetic resonance imaging scans, no amyloid was reported, at histopathology, spherical amyloid within the pituitary tumor was found in abundance. The patient underwent surgery without any trial of cabergoline due to rapid deterioration of vision.

Conclusion: Prolactinomas with amyloid deposits are known not to respond to dopamine agonists (cabergoline) by a reduction in size and may ,in fact increase in volume. Therefore, we recommend that in prolactinomas not responding to medical therapy, deposition of amyloid has to be considered as a cause for failure of medical therapy and surgery and then has to be offered pronto.

Keywords: Amyloid; cabergoline; pituitary tumor; prolactin.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
(a and b) Preoperative magnetic resonance imaging T2-weighted coronal and sagittal images showing heterogeneous isointensity with cystic areas extending superiorly to the hypothalamus and descending into sphenoid sinus
Figure 2
Figure 2
Neuronavigation intraoperative snapshot at the end of excision
Figure 3
Figure 3
Postoperative T2 magnetic resonance imaging showing large excision with small superior residue and fat chiasmopexy below
Figure 4
Figure 4
HP slide Microphotograph of tumor with masses of spherical, laminated eosinophilic amyloid material (H and E)
Figure 5
Figure 5
HP microphotograph of tumor Congo red staining showing apple-green birefringence under polarized light
See this image and copyright information in PMC

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References

    1. Barr R, Lampert P. Intrasellar amyloid tumor. Acta Neuropathol. 1972;21:83–6. - PubMed
    1. Kuratsu J, Matsukado Y, Miura M. Prolactinoma of pituitary with associated amyloid-like substances. Case report. J Neurosurg. 1983;59:1067–70. - PubMed
    1. Landolt AM, Heitz PU. Differentiation of two types of amyloid occurring in pituitary adenomas. Pathol Res Pract. 1988;183:552–4. - PubMed
    1. Saitoh Y, Mori H, Matsumoto K, Ushio Y, Hayakawa T, Mori S. Accumulation of amyloid in pituitary adenomas. Acta Neuropathol. 1985;68:87–92. - PubMed
    1. Glenner GG, Eanes ED, Bladen HA, Linke RP, Termine JD. Beta-pleated sheet fibrils. A comparison of native amyloid with synthetic protein fibrils. J Histochem Cytochem. 1974;22:1141–58. - PubMed