Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Sep 1:25:18.
doi: 10.1186/s40885-019-0125-9. eCollection 2019.

The comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function

Hack-Lyoung Kim  1 , Woo-Hyun Lim  1 , Jae-Bin Seo  1 , Sang-Hyun Kim  1 , Zoo-Hee Zo  1 , Myung-A Kim  1
Affiliations

The comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function

Hack-Lyoung Kim et al. Clin Hypertens. .

Abstract

Background: This study was performed to compare the associations of brachial-ankle pulse wave velocity (baPWV) and central blood pressure (CBP) measurements with left ventricular (LV) geometry and diastolic function.

Methods: A total of 77 subjects (64.5 ± 10.8 years, 67.5% females) without documented cardiovascular disease were prospectively recruited. All subjects underwent transthoracic echocardiography, baPWV and noninvasive measurement of CBP on the same day.

Results: In simple linear correlation analyses, neither baPWV nor CBP was associated with LV mass index or relative wall thickness (P > 0.05 for each). Although baPWV significantly correlated with septal e´ velocity in simple linear correlation analyses (r = 0.258, P = 0.025), the significance was lost after controlling for potential confounder (P = 0.881). In simple linear correlation analyses, central systolic blood pressure (CSBP) and central pulse pressure (CPP) significantly correlated with both septal e´ velocity or E/e´ (P < 0.05 for each); however, neither central diastolic nor mean arterial pressures was associated with both septal e´ velocity and E/e´ (P > 0.05 for each). After controlling for confounders, including age, sex and body mass index, CSBP correlated with septal e´ velocity (β = - 0.258, P = 0.025), but not with E/e´ (P = 0.074). CPP correlated with both septal e´ velocity (β = - 0.300, P = 0.014) and E/e´ (β = 0.428, P = 0.002) in the same multivariable model.

Conclusions: In subjects without documented cardiovascular disease, CSBP and CPP may be more strongly associated with LV diastolic function than baPWV. Further studies with a larger sample size are needed to confirm our results.

Keywords: Arterial stiffness; Central blood pressure, Diastolic function; Left ventricle; Morphology.

PubMed Disclaimer

Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The correlations of central pulse pressure and brachial-ankle PWV with Ee/'. PWV, pulse wave velocity
Fig. 2
Fig. 2
The correlations of central and brachial pulse pressures with E/e'
See this image and copyright information in PMC

References

    1. Lee HY, Oh BH. Aging and arterial stiffness. Circ J. 2010;74:2257–2262. doi: 10.1253/circj.CJ-10-0910. - DOI - PubMed
    1. Ichikawa K, Sakuragi S, Nishihara T, Tsuji M, Mori A, Yokohama F, et al. Influence of arterial stiffness on cardiovascular outcome in patients without high blood pressure. Heart. 2018;104:318–323. - PubMed
    1. Mitchell GF, Hwang SJ, Vasan RS, Larson MG, Pencina MJ, Hamburg NM, et al. Arterial stiffness and cardiovascular events: the Framingham heart study. Circulation. 2010;121:505–511. doi: 10.1161/CIRCULATIONAHA.109.886655. - DOI - PMC - PubMed
    1. Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol. 2010;55:1318–1327. doi: 10.1016/j.jacc.2009.10.061. - DOI - PubMed
    1. Cavalcante JL, Lima JA, Redheuil A, Al-Mallah MH. Aortic stiffness: current understanding and future directions. J Am Coll Cardiol. 2011;57:1511–1522. doi: 10.1016/j.jacc.2010.12.017. - DOI - PubMed

LinkOut - more resources