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. 2019 Sep 1:25:18.
doi: 10.1186/s40885-019-0125-9. eCollection 2019.

The comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function

Hack-Lyoung Kim  1 , Woo-Hyun Lim  1 , Jae-Bin Seo  1 , Sang-Hyun Kim  1 , Zoo-Hee Zo  1 , Myung-A Kim  1
Affiliations

The comparison of the impact of arterial stiffness and central pressure on left ventricular geometry and diastolic function

Hack-Lyoung Kim et al. Clin Hypertens. .

Abstract

Background: This study was performed to compare the associations of brachial-ankle pulse wave velocity (baPWV) and central blood pressure (CBP) measurements with left ventricular (LV) geometry and diastolic function.

Methods: A total of 77 subjects (64.5 ± 10.8 years, 67.5% females) without documented cardiovascular disease were prospectively recruited. All subjects underwent transthoracic echocardiography, baPWV and noninvasive measurement of CBP on the same day.

Results: In simple linear correlation analyses, neither baPWV nor CBP was associated with LV mass index or relative wall thickness (P > 0.05 for each). Although baPWV significantly correlated with septal e´ velocity in simple linear correlation analyses (r = 0.258, P = 0.025), the significance was lost after controlling for potential confounder (P = 0.881). In simple linear correlation analyses, central systolic blood pressure (CSBP) and central pulse pressure (CPP) significantly correlated with both septal e´ velocity or E/e´ (P < 0.05 for each); however, neither central diastolic nor mean arterial pressures was associated with both septal e´ velocity and E/e´ (P > 0.05 for each). After controlling for confounders, including age, sex and body mass index, CSBP correlated with septal e´ velocity (β = - 0.258, P = 0.025), but not with E/e´ (P = 0.074). CPP correlated with both septal e´ velocity (β = - 0.300, P = 0.014) and E/e´ (β = 0.428, P = 0.002) in the same multivariable model.

Conclusions: In subjects without documented cardiovascular disease, CSBP and CPP may be more strongly associated with LV diastolic function than baPWV. Further studies with a larger sample size are needed to confirm our results.

Keywords: Arterial stiffness; Central blood pressure, Diastolic function; Left ventricle; Morphology.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
The correlations of central pulse pressure and brachial-ankle PWV with Ee/'. PWV, pulse wave velocity
Fig. 2
Fig. 2
The correlations of central and brachial pulse pressures with E/e'
See this image and copyright information in PMC

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