Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Jul;48(7):1278-1283.

Amplitude Integrated Electroencephalogram Study of the Effect of Caffeine Citrate on Brain Development in Low Weight Infants with Apnea

Dong Yang  1 , Bin Zhou  1 , Bao Jin  1 , Xiao Liu  1 , Yun Wang  1
Affiliations

Amplitude Integrated Electroencephalogram Study of the Effect of Caffeine Citrate on Brain Development in Low Weight Infants with Apnea

Dong Yang et al. Iran J Public Health. 2019 Jul.

Abstract

Background: To investigate the effect of caffeine citrate on the integrated brain electroencephalogram (EEG) of apnea and low birth weight infants.

Methods: Overall, 212 infants with apnea and low birth weight admitted to Xuzhou Central Hospital from June 2016 to June 2018 were enrolled. The infants were divided into control group and observation group according to the random number table method, 106 cases in each group. Infants in control group were treated with aminophylline, and infants in the observation group were given caffeine citrate. All children were continuously tested by digital amplitude integrated brain function monitor. The amplitude-integrated electroencephalogram (aEEG) was used to detect sleep arousal cycle (Cy), graphic continuity (Co), lower edge amplitude value (LB) scores, aEEG continuous voltage and periodic occurrence rate, narrowband voltage and bandwidth.

Results: After treatment, scores of Cy, Co and LB increased in both groups, and the scores were significantly higher in observation group than in control group (P=0.029, 0.017, 0.047). After treatment, continuous voltage positive rate, sleep-wake cycle occurrence rate, and narrow-band lower boundary voltage increased in both groups, and the values were significantly higher in observation group than in control group (P=0.011, 0.042). After treatment, aEEG detection bandwidth and the upper boundary voltage of the narrow band decreased in both groups, and the values were significantly lower in observation group than in control group (P=0.007, 0.020, 0.032).

Conclusion: Citrate caffeine can alleviate the brain development of low-weight infants with apnea, improve brain electrical activity and promote brain function and maturity.

Keywords: Aminophylline; Amplitude integrated EEG; Apnea and low birth weight; Brain development; Citrate caffeine.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interests The authors declare that there is no conflict of interest.

References

    1. Ogawa Y, Irikura M, Kobaru Y, et al. (2015). Population pharmacokinetics of doxapram in low-birth-weight Japanese infants with apnea. Eur J Pediatr, 174: 509–518. - PubMed
    1. DeMeo SD, Raman SR, Hornik CP, Wilson CC, Clark R, Smith PB. (2015). Adverse Events after Routine Immunization of Extremely Low-Birth-Weight Infants. JAMA Pediatr, 169: 740–745. - PMC - PubMed
    1. Benavente-Fernandez I, Lubian-Lopez SP, Jimenez-Gomez G, Lechuga-Sancho AM, Garcia-Alloza M. (2015). Low-voltage pattern and absence of sleep-wake cycles are associated with severe hemorrhage and death in very preterm infants. Eur J Pediatr, 174: 85–90. - PubMed
    1. Rangel MO, Morales Demori R, Voll ST, Wassouf M, Dick R, Doukky R. (2015). Severe chronic kidney disease as a predictor of benefit from aminophylline administration in patients undergoing regadenoson stress myocardial perfusion imaging: A substudy of the ASSUAGE and ASSUAGE-CKD trials. J Nucl Cardiol, 22: 1008–1018. - PubMed
    1. Rybak ME, Sternberg MR, Pao CI, Ahluwalia N, Pfeiffer CM. (2015). Urine excretion of caffeine and select caffeine metabolites is common in the U.S. population and associated with caffeine intake. J Nutr, 145: 766–774. - PMC - PubMed

LinkOut - more resources