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. 2018 Sep 13;34(2):148-156.
doi: 10.5606/ArchRheumatol.2019.7000. eCollection 2019 Jun.

Association of Interleukin-17F 7488A/G and 7383A/G Polymorphisms With Rheumatoid Arthritis: A Meta-Analysis

Ping Chen  1 , Guangqiao He  1 , Yi Yang  1 , Yanlong Yang  1 , Liangliang Li  1
Affiliations

Association of Interleukin-17F 7488A/G and 7383A/G Polymorphisms With Rheumatoid Arthritis: A Meta-Analysis

Ping Chen et al. Arch Rheumatol. .

Abstract

Objectives: This meta-analysis aims to summarize and estimate the relationship between rheumatoid arthritis (RA) susceptibility and two polymorphisms of interleukin-17F (IL-17F) 7488A/G and 7383A/G.

Materials and methods: PubMed, Embase and Web of Science were searched up to 01 July 2017. Case-control studies with genotype frequencies data for 7488A/G and 7383A/G were included. The pooled effects were calculated by fixed-effect model or random effects model.

Results: A total of seven publications with 1,409 RA patients and 1,303 controls were included in the present meta-analysis. The results indicated that 7488A/G was significantly associated with increased susceptibility to RA (GA vs. AA: odds ratio [OR]=1.43, 95% confidence interval [CI]: 1.07-1.90, p=0.02; GG vs. AA: OR=3.22, 95% CI: 1.54-6.74, p=0.002; GA+GG vs. AA: OR=1.57, 95% CI: 1.02-2.42, p=0.04; GG vs. GA+AA: OR=3.05, 95% CI: 1.46-6.39, p=0.003). In subgroup analysis, 7488A/G was a strong risk factor in Europeans but not in Americans or Africans. No significant association was found between 7383A/G and RA in overall population or ethnic subgroups by all genetic model comparisons.

Conclusion: This meta-analysis provided evidence that IL-17F 7488A/G polymorphism is associated with increased RA susceptibility, while no clear correlation was found between 7383A/G and RA.

Keywords: Interleukin-17F; meta-analysis; polymorphism; rheumatoid arthritis.

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Conflict of interest statement

Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Figures

Figure 1
Figure 1. Flow chart of literature research and selection of included studies.
Figure 2
Figure 2. Forest plots of meta-analysis of interleukin-17F 7488A/G and rheumatoid arthritis in overall population. A. Heterozygote model (GA vs. AA); B. Homozygote model (GG vs. AA); C. Dominant model (GG+GA vs. AA); D. Recessive model (GG vs. GA+AA). CI: Confidence interval.
Figure 3
Figure 3. Begg's funnel plot for publication bias of interleukin-17F 7488A/G for overall comparison (G vs. A).
See this image and copyright information in PMC

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