Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Nov 30;34(2):225-228.
doi: 10.5606/ArchRheumatol.2019.7020. eCollection 2019 Jun.

Accelerated Nodulosis in a Patient With Rheumatoid Arthritis

Ayşe Ünal Enginar  1 , Hakan Nur  1 , Erdal Gilgil  2 , Cahit Kaçar  1
Affiliations
Case Reports

Accelerated Nodulosis in a Patient With Rheumatoid Arthritis

Ayşe Ünal Enginar et al. Arch Rheumatol. .

Abstract

In patients with rheumatoid arthritis (RA), subcutaneous nodules are the most frequently seen extra-articular findings that are seen in areas of extensor pressure. In this article, we present the case of a RA patient with accelerated nodulosis that started with the use of methotrexate and exacerbated with etanercept and leflunomide treatment.

Keywords: Accelerated nodulosis; anti-tumor necrosis factor drugs; methotrexate; rheumatoid arthritis.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors declared no conflicts of interest with respect to the authorship and/or publication of this article.

Figures

Figure 1
Figure 1. Nodulosis after etanercept. (a) hand, (b) foot
Figure 2
Figure 2. Biopsy in rheumatoid nodule (H-E¥50).
Figure 3
Figure 3. Nodulosis before leflunomide.
Figure 4
Figure 4. Nodulosis after termination of drugs.
See this image and copyright information in PMC

References

    1. Ziff M. The rheumatoid nodule. Arthritis Rheum. 1990;33:761–767. - PubMed
    1. Cunnane G, Warnock M, Fye KH, Daikh DI. Accelerated nodulosis and vasculitis following etanercept therapy for rheumatoid arthritis. Arthritis Rheum. 2002;47:445–449. - PubMed
    1. Kerstens PJ, Boerbooms AM, Jeurissen ME, Fast JH, Assmann KJ, van de Putte LB. Accelerated nodulosis during low dose methotrexate therapy for rheumatoid arthritis. An analysis of ten cases. J Rheumatol. 1992;19:867–871. - PubMed
    1. Kerstens PJ, Boerbooms AM, Jeurissen ME, Fast JH, Assmann KJ, van de Putte LB. Accelerated nodulosis during low dose methotrexate therapy for rheumatoid arthritis. An analysis of ten cases. J Rheumatol. 1992;19:867–871. - PubMed
    1. Langevitz P, Maguire L, Urowitz M. Accelerated nodulosis during azathioprine therapy. Arthritis Rheum. 1991;34:123–124. - PubMed

Publication types

LinkOut - more resources