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Review
. 2019 Dec;106(6):1233-1240.
doi: 10.1002/JLB.4RU0619-197R. Epub 2019 Sep 9.

Th17 cell pathogenicity and plasticity in rheumatoid arthritis

Pei Yang  1 , Fei-Ya Qian  1 , Ming-Fei Zhang  1 , A-Lan Xu  1 , Xiang Wang  1 , Bao-Ping Jiang  1 , Ling-Ling Zhou  1
Affiliations
Review

Th17 cell pathogenicity and plasticity in rheumatoid arthritis

Pei Yang et al. J Leukoc Biol. 2019 Dec.

Abstract

CD4+ Th cells play an important role in the development of rheumatoid arthritis (RA) by regulating adaptive immune response. As major subsets of CD4+ Th cells, Th17 cells can produce a large number of hallmark cytokines such as IL-17A and IL-17F, which participate in host defense and immune homeostasis. However, increasing researches have shown that Th17 cells are unstable and exhibit a certain degree of plasticity, which aggravates their pathogenicity. Furthermore, the plasticity and pathogenicity of Th17 cells are closely related with the disease activity in RA. In this paper, the characteristics including phenotype, differentiation, plasticity, and pathogenicity of Th17 cells in RA will be systematically summarized. This will contribute to clarify the immunologic mechanism of RA and further provide a novel strategy for the clinical treatment of autoimmune diseases.

Keywords: Th17 cells; pathogenicity; plasticity; rheumatoid arthritis.

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