Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Dec;106(6):1233-1240.
doi: 10.1002/JLB.4RU0619-197R. Epub 2019 Sep 9.

Th17 cell pathogenicity and plasticity in rheumatoid arthritis

Pei Yang  1 , Fei-Ya Qian  1 , Ming-Fei Zhang  1 , A-Lan Xu  1 , Xiang Wang  1 , Bao-Ping Jiang  1 , Ling-Ling Zhou  1
Affiliations
Review

Th17 cell pathogenicity and plasticity in rheumatoid arthritis

Pei Yang et al. J Leukoc Biol. 2019 Dec.

Abstract

CD4+ Th cells play an important role in the development of rheumatoid arthritis (RA) by regulating adaptive immune response. As major subsets of CD4+ Th cells, Th17 cells can produce a large number of hallmark cytokines such as IL-17A and IL-17F, which participate in host defense and immune homeostasis. However, increasing researches have shown that Th17 cells are unstable and exhibit a certain degree of plasticity, which aggravates their pathogenicity. Furthermore, the plasticity and pathogenicity of Th17 cells are closely related with the disease activity in RA. In this paper, the characteristics including phenotype, differentiation, plasticity, and pathogenicity of Th17 cells in RA will be systematically summarized. This will contribute to clarify the immunologic mechanism of RA and further provide a novel strategy for the clinical treatment of autoimmune diseases.

Keywords: Th17 cells; pathogenicity; plasticity; rheumatoid arthritis.

PubMed Disclaimer

References

REFERENCES

    1. Gravallese EM. Bone destruction in arthritis. Ann Rheum Dis. 2002;61(Suppl. 2):ii84-6.
    1. Radic M, Martinovic Kaliterna D, Radic J. Overview of vasculitis and vasculopathy in rheumatoid arthritis-something to think about. Clin Rheumatol. 2013;32:937-942.
    1. Turesson C, Matteson EL. Vasculitis in rheumatoid arthritis. Curr Opin Rheumatol. 2009;21:35-40.
    1. Deane KD, Demoruelle MK, Kelmenson LB, Kuhn KA, Norris JM, Holers VM. Genetic and environmental risk factors for rheumatoid arthritis. Best practice & research. Clin Rheumatol. 2017;31:3-18.
    1. Alpizar-Rodriguez D, Finckh A. Environmental factors and hormones in the development of rheumatoid arthritis. Semin Immunopathol. 2017;39:461-468.

Publication types

MeSH terms