Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jan;35(1):55-65.
doi: 10.1002/tox.22842. Epub 2019 Sep 9.

Protective effects of trehalose against Mn-induced α-synuclein oligomerization in mice: Involvement of oxidative stress and autophagy

Meng-Jiao Jing, Kuan Liu, Chang Liu, Dong-Ying Yan, Zhuo Ma, Can Wang, Yu Deng, Wei Liu, Bin Xu  1
Affiliations

Protective effects of trehalose against Mn-induced α-synuclein oligomerization in mice: Involvement of oxidative stress and autophagy

Meng-Jiao Jing et al. Environ Toxicol. 2020 Jan.

Abstract

Overexposure to manganese (Mn) is widely known to induce alpha-synuclein (α-Syn) oligomerization, which has been attributed to the oxidative damage of α-Syn protein. Trehalose has been shown to induce autophagy and serve as a chemical chaperone, but little information has been reported about its effect on Mn-induced α-Syn oligomerization. In this study, we investigate whether trehalose can effectively interfere with Mn-induced α-Syn oligomerization, using different concentrations of trehalose (2% and 4% (g/vol [mL])) in a mouse model of manganism. After 6 weeks of exposure to Mn, both oxidative stress and autophagy were activated and resulted in α-Syn oligomerization and neuronal cell damage in the mouse brain tissue. Our results also revealed that pretreatment with trehalose significantly reduced the oxidative damage to α-Syn protein and increased autophagy activation. These findings clearly demonstrated that trehalose can relieve Mn-induced α-Syn oligomerization and neuronal cell damage through its anti-oxidative and autophagy-inducing effects.

Keywords: alpha-synuclein oligomerization; autophagy; manganese; oxidive stress; trehalose.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

REFERENCES

    1. Pfalzer AC, Bowman AB. Relationships between essential manganese biology and manganese toxicity in neurological disease. Curr Environ Health Rep. 2017;4(2):223-228.
    1. Langley MR, Ghaisas S, Ay M, et al. Manganese exposure exacerbates progressive motor deficits and neurodegeneration in the MitoPark mouse model of Parkinson's disease: relevance to gene and environment interactions in metal neurotoxicity. Neurotoxicology. 2018;64:240-255.
    1. Parmalee NL, Aschner M. Manganese and aging. Neurotoxicology. 2016;56:262-268.
    1. Kawahara M, Kato-Negishi M, Tanaka K. Cross talk between neurometals and amyloidogenic proteins at the synapse and the pathogenesis of neurodegenerative diseases. Metallomics. 2017;9(6):619-633.
    1. Peres TV, Parmalee NL, Martinez-Finley EJ, Aschner M. Untangling the manganese-alpha-Synuclein web. Front Neurosci. 2016;10:364.

LinkOut - more resources