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. 2020 Jan;35(1):55-65.
doi: 10.1002/tox.22842. Epub 2019 Sep 9.

Protective effects of trehalose against Mn-induced α-synuclein oligomerization in mice: Involvement of oxidative stress and autophagy

Meng-Jiao Jing, Kuan Liu, Chang Liu, Dong-Ying Yan, Zhuo Ma, Can Wang, Yu Deng, Wei Liu, Bin Xu  1
Affiliations

Protective effects of trehalose against Mn-induced α-synuclein oligomerization in mice: Involvement of oxidative stress and autophagy

Meng-Jiao Jing et al. Environ Toxicol. 2020 Jan.

Abstract

Overexposure to manganese (Mn) is widely known to induce alpha-synuclein (α-Syn) oligomerization, which has been attributed to the oxidative damage of α-Syn protein. Trehalose has been shown to induce autophagy and serve as a chemical chaperone, but little information has been reported about its effect on Mn-induced α-Syn oligomerization. In this study, we investigate whether trehalose can effectively interfere with Mn-induced α-Syn oligomerization, using different concentrations of trehalose (2% and 4% (g/vol [mL])) in a mouse model of manganism. After 6 weeks of exposure to Mn, both oxidative stress and autophagy were activated and resulted in α-Syn oligomerization and neuronal cell damage in the mouse brain tissue. Our results also revealed that pretreatment with trehalose significantly reduced the oxidative damage to α-Syn protein and increased autophagy activation. These findings clearly demonstrated that trehalose can relieve Mn-induced α-Syn oligomerization and neuronal cell damage through its anti-oxidative and autophagy-inducing effects.

Keywords: alpha-synuclein oligomerization; autophagy; manganese; oxidive stress; trehalose.

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References

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