Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 Sep 9;10(1):3743.
doi: 10.1038/s41467-019-11748-y.

Orbitrap journey: taming the ion rings

Affiliations

Orbitrap journey: taming the ion rings

Alexander Makarov. Nat Commun. .

Abstract

The establishment of the Orbitrap analyzer as a major player in mass spectrometry based proteomics is traced back to the first public presentation of this technology 20 years ago; when a proof-of-principle application led the way to further advancements and biological applications.

PubMed Disclaimer

Conflict of interest statement

A.M. is an employee of Thermo Fisher Scientific, the manufacturer of the Orbitrap instrumentation described in this article.

References

    1. Gall, L. N., Golikov, Y. K., Aleksandrov, M. L., Pechalina, Y. E., & Holin, N. A. USSR Inventor’s Certificate #1247973 (1986).
    1. Yamashita M, Fenn JB. Electrospray ion source. Another variation on the free-jet theme. J. Phys. Chem. 1984;88:4451–4459. doi: 10.1021/j150664a002. - DOI
    1. Alexandrov ML, et al. Ion extraction from solutions at atmospheric-pressure-a method of mass-spectrometric analysis of bioorganic substances. Dokl. Akad. Nauk SSSR. 1984;277:379–383.
    1. Tanaka K, et al. Protein and polymer analysis up to m/z 100.000 by laser ionisation time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 1988;2:151–153. doi: 10.1002/rcm.1290020802. - DOI
    1. Karas M, Hillenkamp F. Laser desorption ionisation of proteins with molecular masses exceeding 10.000 daltons. Anal. Chem. 1988;60:2299–2301. doi: 10.1021/ac00171a028. - DOI - PubMed