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Editorial
. 2019 Oct 1;58(10):1712-1714.
doi: 10.1093/rheumatology/kez276.

Systemic lupus erythematosus - a disease of two halves?

Mark N Lazarus  1
Affiliations
Editorial

Systemic lupus erythematosus - a disease of two halves?

Mark N Lazarus. Rheumatology (Oxford). .
No abstract available

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Figures

<sc>Fig</sc>. 1
Fig. 1
Proposed model of SLE Proposed model of SLE showing how production of antibodies by short or long-lived plasma cells in the peripheral or central compartments leads to different disease manifestations. This model hypothesizes that in the peripheral compartment CXCR3+TPH cells help B cells to form SLP in ELT, while in the central compartment CXCR5+TFH cells help B cells to form LLP in SLO. These two processes are likely to result in a spectrum of immunopathology, from localized T-cell and antibody-mediated damage to multi-systemic manifestations and cytopaenias caused by circulating antibodies and immune complex deposition. Certain processes, for example how autoantibodies cross the vascular endothelium from the circulation, are unclear and might require additional factors that are not currently known. B: B cell; ELT: ectopic lymphoid tissue; L: lymphoid progenitor cell; LLP: long-lived plasma cells; SLO: secondary lymphoid organs; SLP: short-lived plasma cells; T : T cell; TFH: follicular helper T cells; TPH: peripheral helper T cells.
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References

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