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Review
. 2019 Nov;22(6):407-412.
doi: 10.1097/MCO.0000000000000600.

Fatty acid-binding proteins: functional understanding and diagnostic implications

Heli Xu  1   2 , Anastasia Diolintzi  3   2 , Judith Storch  1   2
Affiliations
Review

Fatty acid-binding proteins: functional understanding and diagnostic implications

Heli Xu et al. Curr Opin Clin Nutr Metab Care. 2019 Nov.

Abstract

Purpose of review: Fatty acid-binding proteins (FABPs) are a family of small, abundant proteins with highly tissue-specific expression patterns whose different functions remain incompletely understood. The purpose of this review is to summarize recent findings regarding FABP functions and mechanisms of action, including their potential utilization as serum markers of tissue-specific metabolic diseases.

Recent findings: FABPs are important not only in their tissues of origin but also appear to influence the metabolism and function of tissues distal to their sites of expression. This may be secondary to metabolic changes in their primary tissues, and/or a result of FABP secretion from these tissues leading to effects on distal sites. Their levels in the circulation are increasingly explored as potential biomarkers for tissue-specific disease prognosis and progression.

Summary: The nine fatty acid-binding members of the FABP family have unique tissue-specific functions and important secondary effects on tissues in which they are not expressed. For many of the FABPs, circulating levels may be indicative of disease processes related to their primary tissues, and may influence physiological function in distal tissues.

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Conflict of interest statement

Conflicts of interest

There are no conflicts of interest.

References

    1. Storch J, Corsico B. The emerging functions and mechanisms of mammalian fatty acid–binding proteins. Annu Rev Nutr 2008; 28:73–95. - PubMed
    1. Lin J, Zheng S, Attie AD, et al. Perilipin 5 and liver fatty acid binding protein function to restore quiescence in mouse hepatic stellate cells. J Lipid Res 2018; 59:416–428. - PMC - PubMed

    2. The study shows novel protein–protein interaction between liver fatty acid-binding protein (FABP) (LFABP) and perilipin 5, providing a mechanistic link to hepatic stellate cell activation and fibrosis.

    1. Newberry EP, Xie Y, Kennedy SM, et al. Prevention of hepatic fibrosis with liver microsomal triglyceride transfer protein deletion in liver fatty acid binding protein null mice. Hepatology 2017; 65:836–852. - PMC - PubMed
    1. Martin GG, Landrock D, Chung S, et al. Loss of fatty acid binding protein-1 alters the hepatic endocannabinoid system response to a high-fat diet. J Lipid Res 2017; 58:2114–2126. - PMC - PubMed
    1. Martin GG, Landrock D, Chung S, et al. Fabp1 gene ablation inhibits high-fat diet-induced increase in brain endocannabinoids. J Neurochem 2017; 140:294–306. - PMC - PubMed

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