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. 2019 Sep 10;322(10):957-973.
doi: 10.1001/jama.2019.12803.

Association Between Dialysis Facility Ownership and Access to Kidney Transplantation

Jennifer C Gander  1 , Xingyu Zhang  2 , Katherine Ross  3   4 , Adam S Wilk  5 , Laura McPherson  3 , Teri Browne  6 , Stephen O Pastan  7 , Elizabeth Walker  3 , Zhensheng Wang  3   8 , Rachel E Patzer  3   4   8
Affiliations

Association Between Dialysis Facility Ownership and Access to Kidney Transplantation

Jennifer C Gander et al. JAMA. .

Retracted and republished in

Abstract

Importance: For-profit (vs nonprofit) dialysis facilities have historically had lower kidney transplantation rates, but it is unknown if the pattern holds for living donor and deceased donor kidney transplantation, varies by facility ownership, or has persisted over time in a nationally representative population.

Objective: To determine the association between dialysis facility ownership and placement on the deceased donor kidney transplantation waiting list, receipt of a living donor kidney transplant, or receipt of a deceased donor kidney transplant.

Design, setting, and participants: Retrospective cohort study that included 1 478 564 patients treated at 6511 US dialysis facilities. Adult patients with incident end-stage kidney disease from the US Renal Data System (2000-2016) were linked with facility ownership (Dialysis Facility Compare) and characteristics (Dialysis Facility Report).

Exposures: The primary exposure was dialysis facility ownership, which was categorized as nonprofit small chains, nonprofit independent facilities, for-profit large chains (>1000 facilities), for-profit small chains (<1000 facilities), and for-profit independent facilities.

Main outcomes and measures: Access to kidney transplantation was defined as time from initiation of dialysis to placement on the deceased donor kidney transplantation waiting list, receipt of a living donor kidney transplant, or receipt of a deceased donor kidney transplant. Cumulative incidence differences and multivariable Cox models assessed the association between dialysis facility ownership and each outcome.

Results: Among 1 478 564 patients, the median age was 66 years (interquartile range, 55-76 years), with 55.3% male, and 28.1% non-Hispanic black patients. Eighty-seven percent of patients received care at a for-profit dialysis facility. A total of 109 030 patients (7.4%) received care at 435 nonprofit small chain facilities; 78 287 (5.3%) at 324 nonprofit independent facilities; 483 988 (32.7%) at 2239 facilities of large for-profit chain 1; 482 689 (32.6%) at 2082 facilities of large for-profit chain 2; 225 890 (15.3%) at 997 for-profit small chain facilities; and 98 680 (6.7%) at 434 for-profit independent facilities. During the study period, 121 680 patients (8.2%) were placed on the deceased donor waiting list, 23 762 (1.6%) received a living donor kidney transplant, and 49 290 (3.3%) received a deceased donor kidney transplant. For-profit facilities had lower 5-year cumulative incidence differences for each outcome vs nonprofit facilities (deceased donor waiting list: -13.2% [95% CI, -13.4% to -13.0%]; receipt of a living donor kidney transplant: -2.3% [95% CI, -2.4% to -2.3%]; and receipt of a deceased donor kidney transplant: -4.3% [95% CI, -4.4% to -4.2%]). Adjusted Cox analyses showed lower relative rates for each outcome among patients treated at all for-profit vs all nonprofit dialysis facilities: deceased donor waiting list (hazard ratio [HR], 0.36 [95% CI, 0.35 to 0.36]); receipt of a living donor kidney transplant (HR, 0.52 [95% CI, 0.51 to 0.54]); and receipt of a deceased donor kidney transplant (HR, 0.44 [95% CI, 0.44 to 0.45]).

Conclusions and relevance: Among US patients with end-stage kidney disease, receiving dialysis at for-profit facilities compared with nonprofit facilities was associated with a lower likelihood of accessing kidney transplantation. Further research is needed to understand the mechanisms behind this association.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Pastan reported receiving compensation and travel funds from ESRD Network 6 and receiving compensation from Retrophin Corporation. He is a shareholder of Old National Dialysis and a former minority owner of Fresenius College Park Dialysis; these companies were involved in litigation with Fresenius Medical Care, which has been resolved by binding arbitration. No other disclosures were reported.

Figures

Figure 1.
Figure 1.. Data Merge and Cohort Selection to Assess the Association Between Dialysis Facility Ownership and Access to Kidney Transplantation
aThere were 2948 dialysis facilities within the US Renal Data System that could not be linked to the Dialysis Facility Compare and Dialysis Facility Report cohort. There were 13 facilities that were in the Dialysis Facility Compare and Dialysis Facility Report cohort that could not be linked to the US Renal Data System. bOnly a single observation for when the event (placement on the deceased donor kidney transplantation waiting list or receipt of a kidney transplant) occurred was included. The last observation was included for patients who died or were censored at the end of the study (December 31, 2016).
Figure 2.
Figure 2.. Two-Year Incidence Rates and Rate Differences for Kidney Transplant, 2001-2016
Follow-up time was truncated on December 31 of each 2-year period. The unadjusted 2-year incidence rates (per 100 person-years) for placement on the deceased donor waiting list, receipt of a living donor kidney transplant, and receipt of a deceased donor kidney transplant were calculated by dividing the count of events for incident patients by the number of incident patients in the dialysis facility ownership group for each interval. The 2-year incident rate differences (per 100 person-years) were calculated between all nonprofit facilities and all for-profit facilities.
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References

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