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. 2020 Jul 27;71(3):593-600.
doi: 10.1093/cid/ciz853.

Weight Gain Associated With Integrase Stand Transfer Inhibitor Use in Women

Anne Marie Kerchberger  1 , Anandi N Sheth  2 , Christine D Angert  3 , C Christina Mehta  3 , Nathan A Summers  2 , Ighovwerha Ofotokun  2 , Deborah Gustafson  4 , Sheri D Weiser  5 , Anjali Sharma  6 , Adaora A Adimora  7 , Audrey L French  8 , Michael Augenbraun  9 , Jennifer Cocohoba  10 , Seble Kassaye  11 , Hector Bolivar  12 , Usha Govindarajulu  13 , Deborah Konkle-Parker  14 , Elizabeth T Golub  15 , Cecile D Lahiri  2
Affiliations

Weight Gain Associated With Integrase Stand Transfer Inhibitor Use in Women

Anne Marie Kerchberger et al. Clin Infect Dis. .

Abstract

Background: Integrase strand-transfer inhibitor (INSTI)-based antiretroviral therapy (ART) is recommended for human immunodeficiency virus (HIV) management. Although studies have suggested associations between INSTIs and weight gain, women living with HIV (WLHIV) have been underrepresented in research. We evaluated the effect of switching or adding INSTIs among WLHIV.

Methods: Women enrolled in the Women's Interagency HIV Study (WIHS) from 2006-2017 who switched to or added an INSTI to ART (SWAD group) were compared to women on non-INSTI ART (STAY group). Body weight, body mass index (BMI), percentage body fat (PBF), and waist, hip, arm, and thigh circumferences were measured 6-12 months before and 6-18 months after the INSTI switch/add in SWAD participants, with comparable measurement time points in STAY participants. Linear regression models compared changes over time by SWAD/STAY group, adjusted for age, race, WIHS site, education, income, smoking status, and baseline ART regimen.

Results: We followed 1118 women (234 SWAD and 884 STAY) for a mean of 2.0 years (+/- 0.1 standard deviation [SD]; mean age 48.8 years, SD +/- 8.8); 61% were Black. On average, compared to the STAY group, the SWAD group experienced mean greater increases of 2.1 kg in body weight, 0.8 kg/m2 in BMI, 1.4% in PBF, and 2.0, 1.9, 0.6, and 1.0 cm in waist, hip, arm, and thigh circumference, respectively (all P values < .05). No differences in magnitudes of these changes were observed by INSTI type.

Conclusions: In WLHIV, a switch to INSTI was associated with significant increases in body weight, body circumferences, and fat percentages, compared to non-INSTI ART. The metabolic and other health effects of these changes deserve further investigation.

Keywords: HIV positive; integrase strand transfer inhibitors; weight gain; women.

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Figures

Figure 1.
Figure 1.
Study schema. a259 switched to or added an integrase strand transfer inhibitor (INSTI) but did not have 3 postswitch visits with consecutive INSTI use. Abbreviations: ART, antiretroviral therapy; HIV, human immunodeficiency virus; STAY, women who remained on non-INSTI ART during follow-up; SWAD, women who switched to or added an INSTI to ART; WIHS, Women’s Interagency HIV Study.
See this image and copyright information in PMC

References

    1. Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD, Ogden CL. Trends in obesity among adults in the United States, 2005 to 2014. JAMA 2016; 315:2284–91. - PMC - PubMed
    1. Kim DJ, Westfall AO, Chamot E, et al. Multimorbidity patterns in HIV-infected patients: the role of obesity in chronic disease clustering. J Acquir Immune Defic Syndr 2012; 61:600–5. - PMC - PubMed
    1. McCutchan JA, Marquie-Beck JA, Fitzsimons CA, et al. ; CNS HIV Antiretroviral Therapy Effects Research Group. Role of obesity, metabolic variables, and diabetes in HIV-associated neurocognitive disorder. Neurology 2012; 78:485–92. - PMC - PubMed
    1. Koethe JR, Jenkins CA, Lau B, et al. ; North American Acquired Immunodeficiency Syndrome Cohort Collaboration on Research and Design (NA-ACCORD) Rising obesity prevalence and weight gain among adults starting antiretroviral therapy in the United States and Canada. AIDS Res Hum Retroviruses 2016; 32:50–8. - PMC - PubMed
    1. Bares SH, Smeaton LM, Xu A, Godfrey C, McComsey GA. HIV-infected women gain more weight than HIV-infected men following the initiation of antiretroviral therapy. J Womens Health 2018; 27:1162–9. - PMC - PubMed

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