Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Feb 1;49(1):20-21i.
doi: 10.1093/ije/dyz174.

Cohort Profile: East London Genes & Health (ELGH), a community-based population genomics and health study in British Bangladeshi and British Pakistani people

Sarah Finer  1 , Hilary C Martin  2 , Ahsan Khan  3 , Karen A Hunt  1 , Beverley MacLaughlin  1 , Zaheer Ahmed  1 , Richard Ashcroft  4 , Ceri Durham  5 , Daniel G MacArthur  6   7 , Mark I McCarthy  8   9   10 , John Robson  1 , Bhavi Trivedi  1 , Chris Griffiths  1 , John Wright  11 , Richard C Trembath  12 , David A van Heel  1
Affiliations

Cohort Profile: East London Genes & Health (ELGH), a community-based population genomics and health study in British Bangladeshi and British Pakistani people

Sarah Finer et al. Int J Epidemiol. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
ELGH study design. Stage 1 and 2 studies have commenced. Stage 3 and 4 studies will commence in 2019.
Figure 2.
Figure 2.
Population pyramid showing age and sex of ELGH volunteers (n = 29 370) versus the total population of British Bangladeshi and British Pakistani people (n = 152 564) in east London (all NHS GP-registered adults residing in the London Boroughs of City and Hackney, Newham, Tower Hamlets, Waltham Forest), aged ≥ 16 years.
Figure 3.
Figure 3.
Distribution of levels of autozygosity as a fraction of the genome in ELGH volunteers, split according to self-reported parental relatedness and ethnicity (Tukey box plot showing median, lower and upper quartiles, quartiles +/- 1.5x interquartile range, and outliers).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

  • Polygenic Risk Scores for Cardiovascular Disease: A Scientific Statement From the American Heart Association.
    O'Sullivan JW, Raghavan S, Marquez-Luna C, Luzum JA, Damrauer SM, Ashley EA, O'Donnell CJ, Willer CJ, Natarajan P; American Heart Association Council on Genomic and Precision Medicine; Council on Clinical Cardiology; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular Radiology and Intervention; Council on Lifestyle and Cardiometabolic Health; and Council on Peripheral Vascular Disease. O'Sullivan JW, et al. Circulation. 2022 Aug 23;146(8):e93-e118. doi: 10.1161/CIR.0000000000001077. Epub 2022 Jul 18. Circulation. 2022. PMID: 35862132 Free PMC article. Review.
  • Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum.
    Venkatesh SS, Wittemans LBL, Palmer DS, Baya NA, Ferreira T, Hill B, Lassen FH, Parker MJ, Reibe S, Elhakeem A, Banasik K, Bruun MT, Erikstrup C, Jensen BA, Juul A, Mikkelsen C, Nielsen HS, Ostrowski SR, Pedersen OB, Rohde PD, Sorensen E, Ullum H, Westergaard D, Haraldsson A, Holm H, Jonsdottir I, Olafsson I, Steingrimsdottir T, Steinthorsdottir V, Thorleifsson G, Figueredo J, Karjalainen MK, Pasanen A, Jacobs BM, Hubers N; Genes & Health Research Team; Estonian Biobank Research Team; Estonian Health Informatics Research Team; DBDS Genomic Consortium; FinnGen; Lippincott M, Fraser A, Lawlor DA, Timpson NJ, Nyegaard M, Stefansson K, Magi R, Laivuori H, van Heel DA, Boomsma DI, Balasubramanian R, Seminara SB, Chan YM, Laisk T, Lindgren CM. Venkatesh SS, et al. medRxiv [Preprint]. 2024 Mar 20:2024.03.19.24304530. doi: 10.1101/2024.03.19.24304530. medRxiv. 2024. Update in: Nat Genet. 2025 May;57(5):1107-1118. doi: 10.1038/s41588-025-02156-8. PMID: 38562841 Free PMC article. Updated. Preprint.
  • Assembling unmapped reads reveals hidden variation in South Asian genomes.
    Das A, Biddanda A, McCoy RC, Schatz MC. Das A, et al. bioRxiv [Preprint]. 2025 May 14:2025.05.14.653340. doi: 10.1101/2025.05.14.653340. bioRxiv. 2025. PMID: 40463162 Free PMC article. Preprint.
  • Overcoming constraints on the detection of recessive selection in human genes from population frequency data.
    Balick DJ, Jordan DM, Sunyaev S, Do R. Balick DJ, et al. Am J Hum Genet. 2022 Jan 6;109(1):33-49. doi: 10.1016/j.ajhg.2021.12.001. Epub 2021 Dec 23. Am J Hum Genet. 2022. PMID: 34951958 Free PMC article.
  • Influence of autozygosity on common disease risk across the phenotypic spectrum.
    Malawsky DS, van Walree E, Jacobs BM, Heng TH, Huang QQ, Sabir AH, Rahman S, Sharif SM, Khan A, Mirkov MU; 23andMe Research Team; Genes & Health Research Team; Kuwahara H, Gao X, Alkuraya FS, Posthuma D, Newman WG, Griffiths CJ, Mathur R, van Heel DA, Finer S, O'Connell J, Martin HC. Malawsky DS, et al. Cell. 2023 Oct 12;186(21):4514-4527.e14. doi: 10.1016/j.cell.2023.08.028. Epub 2023 Sep 26. Cell. 2023. PMID: 37757828 Free PMC article.
See all "Cited by" articles

References

    1. Popejoy AB, Fullerton SM.. Genomics is failing on diversity. Nature 2016;538:161–64. - PMC - PubMed
    1. Office For National Statistics. 2011 Census: Ethnic Group, Local Authorities in the United Kingdom. London: ONS, 2013.
    1. Barnett AH, Dixon AN, Bellary S. et al. Type 2 diabetes and cardiovascular risk in the UK South Asian community. Diabetologia 2006;49:2234–46. - PubMed
    1. Sattar N, Gill J.. Type 2 diabetes in migrant south Asians: mechanisms, mitigation, and management. Lancet Diabetes Endocrinol 2015;3:1004–16. - PubMed
    1. Goodyear M. Public Health Profile of North East London for NE London Sustainability and Transformation Plan 2016. http://archive.eastlondonhcp.nhs.uk/wp-content/uploads/2017/06/NEL-STP-J... (6 September 2018, date last accessed).

Publication types