Cohort Profile: East London Genes & Health (ELGH), a community-based population genomics and health study in British Bangladeshi and British Pakistani people

Sarah Finer¹, Hilary C Martin², Ahsan Khan³, Karen A Hunt¹, Beverley MacLaughlin¹, Zaheer Ahmed¹, Richard Ashcroft⁴, Ceri Durham⁵, Daniel G MacArthur^{6

7}, Mark I McCarthy^{8

9

10}, John Robson¹, Bhavi Trivedi¹, Chris Griffiths¹, John Wright¹¹, Richard C Trembath¹², David A van Heel¹

Affiliations

¹ Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
² Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
³ London Borough of Waltham Forest, Waltham Forest Town Hall, Walthamstow, UK.
⁴ Department of Law, Queen Mary University of London, London, UK.
⁵ Social Action for Health, London, UK.
⁶ Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
⁷ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁸ Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
⁹ Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.
¹⁰ Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK.
¹¹ Bradford Institute for Health Research, Bradford Teaching Hospitals National Health Service (NHS) Foundation Trust, Bradford, UK.
¹² School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

PMID: 31504546
PMCID: PMC7124496
DOI: 10.1093/ije/dyz174

Cohort Profile: East London Genes & Health (ELGH), a community-based population genomics and health study in British Bangladeshi and British Pakistani people

Sarah Finer et al. Int J Epidemiol. 2020.

. 2020 Feb 1;49(1):20-21i.

doi: 10.1093/ije/dyz174.

Authors

Affiliations

¹ Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
² Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
³ London Borough of Waltham Forest, Waltham Forest Town Hall, Walthamstow, UK.
⁴ Department of Law, Queen Mary University of London, London, UK.
⁵ Social Action for Health, London, UK.
⁶ Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
⁷ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁸ Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
⁹ Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK.
¹⁰ Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford, UK.
¹¹ Bradford Institute for Health Research, Bradford Teaching Hospitals National Health Service (NHS) Foundation Trust, Bradford, UK.
¹² School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

PMID: 31504546
PMCID: PMC7124496
DOI: 10.1093/ije/dyz174

No abstract available

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Figures

**Figure 1.**
ELGH study design. Stage 1 and 2 studies have commenced. Stage 3 and 4 studies will commence in 2019.

**Figure 2.**
Population pyramid showing age and sex of ELGH volunteers (n = 29 370) versus the total population of British Bangladeshi and British Pakistani people (n = 152 564) in east London (all NHS GP-registered adults residing in the London Boroughs of City and Hackney, Newham, Tower Hamlets, Waltham Forest), aged ≥ 16 years.

**Figure 3.**
Distribution of levels of autozygosity as a fraction of the genome in ELGH volunteers, split according to self-reported parental relatedness and ethnicity (Tukey box plot showing median, lower and upper quartiles, quartiles +/- 1.5x interquartile range, and outliers).

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References

1. Popejoy AB, Fullerton SM.. Genomics is failing on diversity. Nature 2016;538:161–64. - PMC - PubMed
1. Office For National Statistics. 2011 Census: Ethnic Group, Local Authorities in the United Kingdom. London: ONS, 2013.
1. Barnett AH, Dixon AN, Bellary S. et al. Type 2 diabetes and cardiovascular risk in the UK South Asian community. Diabetologia 2006;49:2234–46. - PubMed
1. Sattar N, Gill J.. Type 2 diabetes in migrant south Asians: mechanisms, mitigation, and management. Lancet Diabetes Endocrinol 2015;3:1004–16. - PubMed
1. Goodyear M. Public Health Profile of North East London for NE London Sustainability and Transformation Plan 2016. http://archive.eastlondonhcp.nhs.uk/wp-content/uploads/2017/06/NEL-STP-J... (6 September 2018, date last accessed).

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Cohort Profile: East London Genes & Health (ELGH), a community-based population genomics and health study in British Bangladeshi and British Pakistani people

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Cohort Profile: East London Genes & Health (ELGH), a community-based population genomics and health study in British Bangladeshi and British Pakistani people

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