Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective

Shinichi Kuriyama^{1

2

3}, Hirohito Metoki^{1

4}, Masahiro Kikuya^{1

5}, Taku Obara^{1

2

6}, Mami Ishikuro^{1

2}, Chizuru Yamanaka¹, Masato Nagai^{1

2}, Hiroko Matsubara¹, Tomoko Kobayashi^{1

2

6}, Junichi Sugawara^{1

2

6}, Gen Tamiya^{1

2

7}, Atsushi Hozawa^{1

2}, Naoki Nakaya^{1

8}, Naho Tsuchiya^{1

2}, Tomohiro Nakamura^{1

2}, Akira Narita^{1

2}, Mana Kogure^{1

2}, Takumi Hirata^{1

2}, Ichiro Tsuji^{1

2}, Fuji Nagami^{1

2}, Nobuo Fuse^{1

2

6}, Tomohiko Arai¹, Yoshio Kawaguchi¹, Shinichi Higuchi¹, Masaki Sakaida¹, Yoichi Suzuki^{1

9}, Noriko Osumi^{1

2}, Keiko Nakayama^{1

2}, Kiyoshi Ito^{1

2

3}, Shinichi Egawa^{1

2

3

6}, Koichi Chida^{1

2

3

6}, Eiichi Kodama^{1

2

3

6}, Hideyasu Kiyomoto¹, Tadashi Ishii^{1

2

6}, Akito Tsuboi^{1

6

10}, Hiroaki Tomita^{1

2

3

6}, Yasuyuki Taki^{1

2

11}, Hiroshi Kawame^{1

2

6

12}, Kichiya Suzuki^{1

2

6}, Naoto Ishii^{1

2}, Soichi Ogishima^{1

2}, Satoshi Mizuno^{1

2}, Takako Takai-Igarashi^{1

2}, Naoko Minegishi^{1

2}, Jun Yasuda^{1

13}, Kazuhiko Igarashi^{1

2}, Ritsuko Shimizu^{1

2}, Masao Nagasaki^{1

14}, Osamu Tanabe^{1

15}, Seizo Koshiba^{1

2}, Hiroaki Hashizume¹, Hozumi Motohashi^{1

2

11}, Teiji Tominaga^{1

2

6}, Sadayoshi Ito^{1

2

6}, Kozo Tanno^{16

17}, Kiyomi Sakata^{16

17}, Atsushi Shimizu¹⁶, Jiro Hitomi^{16

17}, Makoto Sasaki^{16

17

18}, Kengo Kinoshita^{1

19}, Hiroshi Tanaka^{1

20}, Tadao Kobayashi¹; Tohoku Medical Megabank Project Study Group; Shigeo Kure^{1

2

6}, Nobuo Yaegashi^{1

2

6}, Masayuki Yamamoto^{1

2}

Affiliations

¹ Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
² Graduate School of Medicine, Tohoku University, Sendai, Japan.
³ International Research Institute of Disaster Science, Tohoku University, Sendai, Japan.
⁴ School of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
⁵ School of Medicine, Teikyo University, Tokyo, Japan.
⁶ Tohoku University Hospital, Tohoku University, Sendai, Japan.
⁷ Statistical Genetics Team, RIKEN Center for Advanced Intelligence Project, Tokyo, Japan.
⁸ School of Health and Social Services, Saitama Prefectural University, Koshigaya, Japan.
⁹ Department of Clinical Genetics, Ageo Central General Hospital, Ageo, Japan.
¹⁰ Graduate School of Dentistry, Tohou University, Sendai, Japan.
¹¹ Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
¹² School of Medicine, The Jikei University, Tokyo, Japan.
¹³ Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, Japan.
¹⁴ Graduate School of Medicine, Kyoto University, Kyoto, Japan.
¹⁵ Biosample Research Center, Radiation Effects Research Foundation, Hiroshima, Japan.
¹⁶ Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, Yahaba, Japan.
¹⁷ School of Medicine, Iwate Medical University, Morioka, Japan.
¹⁸ Institute for Biomedical Science, Iwate Medical University, Yahaba, Japan.
¹⁹ Graduate School of Information Sciences, Tohoku University, Sendai, Japan.
²⁰ Laboratory for Promotion of Medical Data Science, Tokyo Medical and Dental University, Tokyo, Japan.

PMID: 31504573
PMCID: PMC7124511
DOI: 10.1093/ije/dyz169

Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective

Shinichi Kuriyama et al. Int J Epidemiol. 2020.

. 2020 Feb 1;49(1):18-19m.

doi: 10.1093/ije/dyz169.

Authors

Affiliations

¹ Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
² Graduate School of Medicine, Tohoku University, Sendai, Japan.
³ International Research Institute of Disaster Science, Tohoku University, Sendai, Japan.
⁴ School of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
⁵ School of Medicine, Teikyo University, Tokyo, Japan.
⁶ Tohoku University Hospital, Tohoku University, Sendai, Japan.
⁷ Statistical Genetics Team, RIKEN Center for Advanced Intelligence Project, Tokyo, Japan.
⁸ School of Health and Social Services, Saitama Prefectural University, Koshigaya, Japan.
⁹ Department of Clinical Genetics, Ageo Central General Hospital, Ageo, Japan.
¹⁰ Graduate School of Dentistry, Tohou University, Sendai, Japan.
¹¹ Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
¹² School of Medicine, The Jikei University, Tokyo, Japan.
¹³ Division of Molecular and Cellular Oncology, Miyagi Cancer Center Research Institute, Natori, Japan.
¹⁴ Graduate School of Medicine, Kyoto University, Kyoto, Japan.
¹⁵ Biosample Research Center, Radiation Effects Research Foundation, Hiroshima, Japan.
¹⁶ Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, Yahaba, Japan.
¹⁷ School of Medicine, Iwate Medical University, Morioka, Japan.
¹⁸ Institute for Biomedical Science, Iwate Medical University, Yahaba, Japan.
¹⁹ Graduate School of Information Sciences, Tohoku University, Sendai, Japan.
²⁰ Laboratory for Promotion of Medical Data Science, Tokyo Medical and Dental University, Tokyo, Japan.

PMID: 31504573
PMCID: PMC7124511
DOI: 10.1093/ije/dyz169

No abstract available

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Figures

**Figure 1.**
Types of prospective cohort studies. The types of prospective cohort studies and their features are presented in this figure. The number of each cohort approximates the historical sequence.

**Figure 2.**
Flow chart of the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) participants. The flow chart shows the inclusion criteria, inclusion route and response rate to invitations to potential participants.

**Figure 3.**
Number of participants according to family role. Both the total number of participants in the ‘fetus’ origin cohort and that in the ‘newborn’ origin cohort are presented.

**Figure 4.**
Number of trio, quadro, hepta and big family sets. Each number shows the number of trio, quadro, hepta, and big family sets.

**Figure 5.**
Cumulative number of participating pregnant women, newborns, and family members (fathers, siblings, grandparents, great-grandparents and extended family members) in the newborn origin cohort. Pregnant women and newborns were linearly recruited, but the recruitment of family members increased quadratically.

See this image and copyright information in PMC

References

1. Fallin MD, Duggal P, Beaty TH.. Genetic epidemiology and public health: the evolution from theory to technology. Am J Epidemiol 2016;183:387–93. - PubMed
1. Gaulton KJ, Ferreira T, Lee Y. et al. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet 2015;47:1415–25. - PMC - PubMed
1. Wellcome Trust Case Control Consortium. Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls. Nature 2010;464:713–20. - PMC - PubMed
1. Roden DM, Pulley JM, Basford MA. et al. Development of a large-scale de-identified DNA biobank to enable personalized medicine. Clin Pharmacol Ther 2008;84:362–69. - PMC - PubMed
1. Karolinska Institutet. KI Biobank. Stockholm: Karolinska Institutet, 2019.

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Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective

Affiliations

Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective

Authors

Affiliations

Figures

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources