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. 2020 Apr 10;46(3):650-660.
doi: 10.1093/schbul/sbz087.

Effect of Risperidone Monotherapy on Dynamic Functional Connectivity of Insular Subdivisions in Treatment-Naive, First-Episode Schizophrenia

Xujun Duan  1   2 , Maolin Hu  3   4   5 , Xinyue Huang  1   2 , Chan Su  1   2 , Xiaofen Zong  3   4   5 , Xia Dong  1   2 , Changchun He  1   2 , Jinming Xiao  1   2 , Haoru Li  1   2 , Jinsong Tang  4   6   7 , Xiaogang Chen  4   6   7 , Huafu Chen  1   2
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Effect of Risperidone Monotherapy on Dynamic Functional Connectivity of Insular Subdivisions in Treatment-Naive, First-Episode Schizophrenia

Xujun Duan et al. Schizophr Bull. .

Abstract

Objective: The insula consists of functionally diverse subdivisions, and each division plays different roles in schizophrenia neuropathology. The current study aimed to investigate the abnormal patterns of dynamic functional connectivity (dFC) of insular subdivisions in schizophrenia and the effect of antipsychotics on these connections.

Methods: Longitudinal study of the dFC of insular subdivisions was conducted in 42 treatment-naive first-episode patients with schizophrenia at baseline and after 8 weeks of risperidone treatment based on resting-state functional magnetic resonance image (fMRI).

Results: At baseline, patients showed decreased dFC variance (less variable) between the insular subdivisions and the precuneus, supplementary motor area and temporal cortex, as well as increased dFC variance (more variable) between the insular subdivisions and parietal cortex, compared with healthy controls. After treatment, the dFC variance of the abnormal connections were normalized, which was accompanied by a significant improvement in positive symptoms.

Conclusions: Our findings highlighted the abnormal patterns of fluctuating connectivity of insular subdivision circuits in schizophrenia and suggested that these abnormalities may be modified after antipsychotic treatment.

Keywords: antipsychotic medication; dynamic functional connectivity; insular subdivision; resting-state fMRI; schizophrenia.

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Figures

Fig. 1.
Fig. 1.
Group differences in dFC variance for left dAI (A) and right dAI (B) (Bonferroni correction at P < .05, combined with AlphaSim correction at P < .008). The histograms show average dFC variance in the target regions for each group. *P < .01, **P < .005, ***P < .001, ****P < .0005.
Fig. 2.
Fig. 2.
Group differences in dFC variance analysis for left PI (A) and right PI (B) (Bonferroni correction at P < .05, combined with AlphaSim correction at P < .008). The histograms show average dFC variance in target regions for each group. *P < .01, **P < .005, ***P < .001, ****P < .0005.
Fig. 3.
Fig. 3.
Group differences in dFC variance analysis for left vAI (A) and vAI (B) (Bonferroni correction at P < .05, combined with AlphaSim correction at P < .008). The histograms show average dFC variance in target regions for each group. *P < .01, **P < .005, ***P < .001, ****P < .0005.
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