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. 2019 Nov;39(11):2077-2081.
doi: 10.1111/liv.14243. Epub 2019 Sep 20.

The medical impact of hepatitis D virus infection in Uzbekistan

Malika Khodjaeva  1 , Nargiz Ibadullaeva  1 , Aziza Khikmatullaeva  1 , Elizaveta Joldasova  1 , Umed Ismoilov  2 , Massimo Colombo  3 , Gian Paolo Caviglia  4 , Mario Rizzetto  4 , Erkin Musabaev  1
Affiliations

The medical impact of hepatitis D virus infection in Uzbekistan

Malika Khodjaeva et al. Liver Int. 2019 Nov.

Abstract

Background & aims: The hepatitis B virus (HBV) is endemic in Uzbekistan but the medical impact of infection with the HBV-dependent hepatitis D virus (HDV) is unknown in the Country. An Hepatology Center was recently established at the Institute of Virology in Tashkent, which has set up a database enlisting patients with chronic viral liver disorders from all over Uzbekistan; it provides an observatory on the current scenario of viral hepatitis in the Country.

Methods: The prevalence of HBV monoinfection, hepatitis C virus (HCV) infection and HDV superinfection on hepatitis B surface antigen (HBsAg)-positive cirrhosis was determined in 6589 patients with viral cirrhosis collected in the last 3 years.

Results: Of 1089, 1150 and 1455 carriers of the HBsAg with cirrhosis recruited in 2016, 2017 and 2018, 834 (76.5%), 926 (80.5%) and 1224 (84%) respectively, had antibody to the HDV. In 2016, 2017 and 2018, the prevalence of HDV infection has been 41%, 45% and 49.1% respectively, largely exceeding the prevalence of HBV monoinfection (12.5%, 11% and 9.3% respectively) and surpassing the prevalence of HCV in 2017 and 2018 (44% and 41.5% respectively). The median age of the patients with HDV cirrhosis was 39 years, distinctly lower than that of HBV and HCV patients (46 and 55).

Conclusions: Superinfection with the HDV is present in over 80% of the HBsAg-positive cirrhosis in Uzbekistan. The HDV appears to be the major cause of advanced viral liver disease and of juvenile cirrhosis in the Country.

Keywords: HBV; HDV; cirrhosis; epidemiology.

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References

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