Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics
- PMID: 31505174
- PMCID: PMC7397519
- DOI: 10.1016/j.devcel.2019.08.009
Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics
Abstract
In a paper recently published in Science (Greenwood et al., 2019), Greenwood and colleagues now describe a fascinating example of how partitioning of a small lipophilic molecule into a phase-separated cellular constituent, the lipid droplet (LD), contributes to its antibacterial action against Mycobacterium tuberculosis.
Copyright © 2019 Elsevier Inc. All rights reserved.
Comment on
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Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages.Science. 2019 Jun 28;364(6447):1279-1282. doi: 10.1126/science.aat9689. Epub 2019 Jun 27. Science. 2019. PMID: 31249058 Free PMC article.
References
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- Barisch C, and Soldati T (2017). Breaking fat! How mycobacteria and other intracellular pathogens manipulate host lipid droplets. Biochimie 141, 54–61. - PubMed
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