Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2019 Sep 9;50(5):530-532.
doi: 10.1016/j.devcel.2019.08.009.

Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics

Affiliations
Comment

Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics

Tobias C Walther et al. Dev Cell. .

Abstract

In a paper recently published in Science (Greenwood et al., 2019), Greenwood and colleagues now describe a fascinating example of how partitioning of a small lipophilic molecule into a phase-separated cellular constituent, the lipid droplet (LD), contributes to its antibacterial action against Mycobacterium tuberculosis.

PubMed Disclaimer

Comment on

References

    1. Altmann R (1890). Die Elementarorganismen und ihre Beziehungen zu den Zellen (Leipzig: Veit & Co.).
    1. Barisch C, and Soldati T (2017). Breaking fat! How mycobacteria and other intracellular pathogens manipulate host lipid droplets. Biochimie 141, 54–61. - PubMed
    1. Greenwood DJ, Dos Santos MS, Huang S, Russell MRG, Collinson LM, MacRae JI, West A, Jiang H, and Gutierrez MG (2019). Subcellular antibiotic visualization reveals a dynamic drug reservoir in infected macrophages. Science 364, 1279–1282. - PMC - PubMed
    1. Meyers NL, Fontaine KA, Kumar GR, and Ott M (2016). Entangled in a membranous web: ER and lipid droplet reorganization during hepatitis C virus infection. Curr. Opin. Cell Biol. 41, 117–124. - PMC - PubMed
    1. Nolan SJ, Romano JD, and Coppens I (2017). Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondii. PLoS Pathog. 13, e1006362. - PMC - PubMed

Publication types

Substances