The Skin in Celiac Disease Patients: The Other Side of the Coin

doi:10.3390/medicina55090578

Review

. 2019 Sep 9;55(9):578.

doi: 10.3390/medicina55090578.

The Skin in Celiac Disease Patients: The Other Side of the Coin

Affiliations

¹ Digestive Physiopathology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy. l.abenavoli@unicz.it.
² Dermatology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy. stefanodastoli@tiscali.it.
³ Dermatology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy. luigibennardo10@gmail.com.
⁴ JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA. lboccuto@ggc.org.
⁵ Clemson University School of Health Research, Clemson University, Clemson, SC 29634, USA. lboccuto@ggc.org.
⁶ Dermatology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy. mariapassante@gmail.com.
⁷ Dermatology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy. martinaeg@hotmail.it.
⁸ Dermatology Unit "Daniele Innocenzi", Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, 04110 Terracina, Italy. proiettilaria@gmail.com.
⁹ Dermatology Unit "Daniele Innocenzi", Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, 04110 Terracina, Italy. concetta.potenza@uniroma1.it.
¹⁰ Digestive Physiopathology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy. luzza@unicz.it.
¹¹ Dermatology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy. steven.nistico@gmail.com.

PMID: 31505858
PMCID: PMC6780714
DOI: 10.3390/medicina55090578

Review

The Skin in Celiac Disease Patients: The Other Side of the Coin

Ludovico Abenavoli et al. Medicina (Kaunas). 2019.

. 2019 Sep 9;55(9):578.

doi: 10.3390/medicina55090578.

Authors

Affiliations

¹ Digestive Physiopathology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy. l.abenavoli@unicz.it.
² Dermatology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy. stefanodastoli@tiscali.it.
³ Dermatology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy. luigibennardo10@gmail.com.
⁴ JC Self Research Institute, Greenwood Genetic Center, Greenwood, SC 29646, USA. lboccuto@ggc.org.
⁵ Clemson University School of Health Research, Clemson University, Clemson, SC 29634, USA. lboccuto@ggc.org.
⁶ Dermatology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy. mariapassante@gmail.com.
⁷ Dermatology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy. martinaeg@hotmail.it.
⁸ Dermatology Unit "Daniele Innocenzi", Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, 04110 Terracina, Italy. proiettilaria@gmail.com.
⁹ Dermatology Unit "Daniele Innocenzi", Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Polo Pontino, 04110 Terracina, Italy. concetta.potenza@uniroma1.it.
¹⁰ Digestive Physiopathology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy. luzza@unicz.it.
¹¹ Dermatology Unit, Department of Health Sciences, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy. steven.nistico@gmail.com.

PMID: 31505858
PMCID: PMC6780714
DOI: 10.3390/medicina55090578

Abstract

Celiac disease (CD) is an autoimmune enteropathy that primarily affects the small intestine and is characterized by atrophy of intestinal villi. The manifestations of the disease improve following a gluten-free diet (GFD). CD is associated with various extra-intestinal diseases. Several skin manifestations are described in CD patients. The present paper reviews all CD-associated skin diseases reported in the literature and tries to analyze the pathogenic mechanisms possibly involved in these associations. Different hypotheses have been proposed to explain the possible mechanisms involved in every association between CD and cutaneous manifestations. An abnormal small intestinal permeability seems to be implicated in various dermatological manifestations. However, most of the associations between CD and cutaneous diseases is based on case reports and case series and a few controlled studies. To better assess the real involvement of the cutaneous district in CD patients, large multicentric controlled clinical trials are required.

Keywords: enteropathy; gluten; gluten-free diet; gut; level of evidences.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

**Figure 1**
Flow chart of the identified and selected studies.

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References

1. Lebwohl B., Sanders D.S., Green P.H.R. Coeliac disease. Lancet. 2018;391:70–81. doi: 10.1016/S0140-6736(17)31796-8. - DOI - PubMed
1. Leonard M.M., Sapone A., Catassi C., Fasano A. Celiac disease and nonceliac gluten sensitivity: A review. JAMA. 2017;318:647–656. doi: 10.1001/jama.2017.9730. - DOI - PubMed
1. Abenavoli L., Proietti I., Zaccone V. Celiac disease: From gluten to skin. Expert. Rev. Clin. Immunol. 2009;5:789–800. doi: 10.1586/eci.09.46. - DOI - PubMed
1. Abenavoli L., Proietti I., Leggio L. Cutaneous manifestations in celiac disease. World J. Gastroenterol. 2006;12:843–852. doi: 10.3748/wjg.v12.i6.843. - DOI - PMC - PubMed
1. Hujoel I.A., Reilly N.R., Rubio-Tapia A. Celiac disease: Clinical features and diagnosis. Gastroenterol. Clin. North Am. 2019;48:19–37. doi: 10.1016/j.gtc.2018.09.001. - DOI - PubMed

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[1] Lebwohl B., Sanders D.S., Green P.H.R. Coeliac disease. Lancet. 2018;391:70–81. doi: 10.1016/S0140-6736(17)31796-8. - DOI - PubMed

[2] Lebwohl B., Sanders D.S., Green P.H.R. Coeliac disease. Lancet. 2018;391:70–81. doi: 10.1016/S0140-6736(17)31796-8. - DOI - PubMed

[3] Leonard M.M., Sapone A., Catassi C., Fasano A. Celiac disease and nonceliac gluten sensitivity: A review. JAMA. 2017;318:647–656. doi: 10.1001/jama.2017.9730. - DOI - PubMed

[4] Leonard M.M., Sapone A., Catassi C., Fasano A. Celiac disease and nonceliac gluten sensitivity: A review. JAMA. 2017;318:647–656. doi: 10.1001/jama.2017.9730. - DOI - PubMed

[5] Abenavoli L., Proietti I., Zaccone V. Celiac disease: From gluten to skin. Expert. Rev. Clin. Immunol. 2009;5:789–800. doi: 10.1586/eci.09.46. - DOI - PubMed

[6] Abenavoli L., Proietti I., Zaccone V. Celiac disease: From gluten to skin. Expert. Rev. Clin. Immunol. 2009;5:789–800. doi: 10.1586/eci.09.46. - DOI - PubMed

[7] Abenavoli L., Proietti I., Leggio L. Cutaneous manifestations in celiac disease. World J. Gastroenterol. 2006;12:843–852. doi: 10.3748/wjg.v12.i6.843. - DOI - PMC - PubMed

[8] Abenavoli L., Proietti I., Leggio L. Cutaneous manifestations in celiac disease. World J. Gastroenterol. 2006;12:843–852. doi: 10.3748/wjg.v12.i6.843. - DOI - PMC - PubMed

[9] Hujoel I.A., Reilly N.R., Rubio-Tapia A. Celiac disease: Clinical features and diagnosis. Gastroenterol. Clin. North Am. 2019;48:19–37. doi: 10.1016/j.gtc.2018.09.001. - DOI - PubMed

[10] Hujoel I.A., Reilly N.R., Rubio-Tapia A. Celiac disease: Clinical features and diagnosis. Gastroenterol. Clin. North Am. 2019;48:19–37. doi: 10.1016/j.gtc.2018.09.001. - DOI - PubMed

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The Skin in Celiac Disease Patients: The Other Side of the Coin

Affiliations

The Skin in Celiac Disease Patients: The Other Side of the Coin

Authors

Affiliations

Abstract

Conflict of interest statement

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